Executive, Activities of Daily Living, and Cholinergic Functions in Parkinson's Disease

NCT ID: NCT00737217

Last Updated: 2013-06-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

74 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-03-31

Study Completion Date

2009-04-30

Brief Summary

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This research study will evaluate functions of memory, thinking, behavior, and daily life activities and how these relate to the measurement of certain chemicals (acetylcholine and dopamine) in the brain using an imaging procedure called positron emission tomography (PET). You may know that in Alzheimer's dementia (dementia is a disease where persons become forgetful and confused), a reduction in the amount of acetylcholine, a "neurotransmitter" substance (a chemical messenger that nerve cells need to communicate with each other), may be responsible for some of the memory and behavioral changes. At the present time, the investigators have no clear information on the levels of acetylcholine in the brain of patients with Parkinson's disease who also have memory or behavioral changes.

Detailed Description

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Conditions

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Parkinson's Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Parkinson's disease

Behavioral assessment/questionnaire

Intervention Type BEHAVIORAL

Complete behavioral assessment/questionnaire

Normal Controls

Behavioral assessment/questionnaire

Intervention Type BEHAVIORAL

Complete behavioral assessment/questionnaire

Interventions

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Behavioral assessment/questionnaire

Complete behavioral assessment/questionnaire

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* PDD: Patients who meet the UK Parkinson's Disease Society Brain Bank Research Center (UKPDSBRC) clinical diagnostic criteria for PD with dementia (MMSE 18-25; n=28; age 50-85 years; M/F) are eligible for the study. Hoehn and Yahr stages I-III.
* PD. Patients with who meet the UKPDSBRC criteria for PD with a MMSE of \>25 (n=28; age 50-85 years; M/F). Hoehn and Yahr stages I-III.
* Normal control subjects (n=16) (age 50-85 years; M/F).
* No current or past history of neurologic or psychiatric illness.

Exclusion Criteria

* Any subjects on cholinergic, anti-cholinergic drugs will be excluded from the study.
* Current or past history of neurologic or psychiatric illness.
Minimum Eligible Age

50 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Michael J. Fox Foundation for Parkinson's Research

OTHER

Sponsor Role collaborator

University of Michigan

OTHER

Sponsor Role lead

Responsible Party

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Nicolaas Bohnen, MD, PhD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Michigan Functional, Cognitive and Mobility Laboratory

Ann Arbor, Michigan, United States

Site Status

Countries

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United States

Other Identifiers

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2005-0464

Identifier Type: -

Identifier Source: org_study_id

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