Social Cognition Dysfunctions in Parkinson's Disease

NCT ID: NCT05230095

Last Updated: 2024-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

24 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-11

Study Completion Date

2024-01-23

Brief Summary

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Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life. Social cognition is a complex system relying on emotion recognition (neurons mirror system (NMS)), the theory of mind (with its two parts: emotional and cognitive), but also on the social and cultural environment and the personal history. The first step in this model is represented by the NMS, which seems to be altered in PD patients for both positive and negative emotions as shown in our preliminary study. The investigator purpose is to investigate the role of the treatment (levodopa and deep brain stimulation) on the functioning of the NMS

Detailed Description

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Conditions

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Parkinson Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Parkinson's disease patients

30 parkinsonian patients scheduled for deep brain stimulation implantation surgery will be recruited

social cognition tests

Intervention Type BEHAVIORAL

The evaluation of social cognition will be carried out using questionnaires and a point lights computer test. During the computer test, participants have to watch several short sequences of interactions between two silhouettes and give an interpretation of the scene.

Patients will be evaluated twice: one time before the surgery and a second time 1 year after surgery.

Healthy volunteers will be evaluated only one time.

Quality of life self-questionnaire

Intervention Type BEHAVIORAL

Quality of life will be assessed using a self-administered questionnaire in the patients group only.

Controls

15 healthy volunteers matched in age and sex will be recruited

social cognition tests

Intervention Type BEHAVIORAL

The evaluation of social cognition will be carried out using questionnaires and a point lights computer test. During the computer test, participants have to watch several short sequences of interactions between two silhouettes and give an interpretation of the scene.

Patients will be evaluated twice: one time before the surgery and a second time 1 year after surgery.

Healthy volunteers will be evaluated only one time.

Interventions

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social cognition tests

The evaluation of social cognition will be carried out using questionnaires and a point lights computer test. During the computer test, participants have to watch several short sequences of interactions between two silhouettes and give an interpretation of the scene.

Patients will be evaluated twice: one time before the surgery and a second time 1 year after surgery.

Healthy volunteers will be evaluated only one time.

Intervention Type BEHAVIORAL

Quality of life self-questionnaire

Quality of life will be assessed using a self-administered questionnaire in the patients group only.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

For all participants:

* Man or woman
* Participant not objecting to participation in the study
* Age ≥ 30 and ≤ 70 years old


* Patients with Parkinson's disease with motor fluctuations and dyskinesias receiving deep-brain stimulation
* Patients able to understand the issues of the study

Exclusion Criteria

For all participants:

* Person deprived of liberty by judicial or administrative decision
* Person subject to a legal protection measure (tutorship, curatorship)
* Person concurrently participating in another research project who may interfere with the results or conclusions of this study


* Person presenting or having presented a neurological or psychiatric pathology
* Person with a serious medical condition
* Person who has exceeded the annual amount of compensation authorized for participation in research protocols
Minimum Eligible Age

30 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Neurology C department, P. Wertheimer Hospital

Bron, , France

Site Status

Countries

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France

Other Identifiers

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2022-A00216-37

Identifier Type: OTHER

Identifier Source: secondary_id

69HCL21_1154

Identifier Type: -

Identifier Source: org_study_id

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