Efficacy of In-bag Morcellation

NCT ID: NCT03281460

Last Updated: 2025-09-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-01-25

Study Completion Date

2019-01-21

Brief Summary

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Laparoscopic mini-invasive surgery supplanted laparotomy for many years, including hysterectomy or myomectomy (less postoperative complications compared to laparotomy) However the US Federal Drug Administration (FDA) strongly warned against the use of power morcellation in 2014 because of the risk of iatrogenic spread of malignant cells.

The hypothesis is that in-bag morcellation may prevent cells dissemination. The investigator compare in this prospective randomized study two groups of patients: group A (in bag-morcellation during laparoscopic myomectomy or hysterectomy) versus group B (morcellation without any bag during laparoscopic myomectomy or hysterectomy)

Detailed Description

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Conditions

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Uterine Myomatosis Laparoscopy Hysterectomy, Vaginal

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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with in-bag morcellation

with More-cell-Safe AMI bag morcellation

Group Type EXPERIMENTAL

laparoscopic myomectomy or hysterectomy with More-cell-Safe AMI bag morcellation

Intervention Type DEVICE

laparoscopic myomectomy or hysterectomy with More-cell-Safe AMI bag morcellation

without any morcellation bag

without any morcellation bag

Group Type ACTIVE_COMPARATOR

laparoscopic myomectomy or hysterectomy without any morcellation bag

Intervention Type PROCEDURE

laparoscopic myomectomy or hysterectomy without any morcellation bag

Interventions

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laparoscopic myomectomy or hysterectomy with More-cell-Safe AMI bag morcellation

laparoscopic myomectomy or hysterectomy with More-cell-Safe AMI bag morcellation

Intervention Type DEVICE

laparoscopic myomectomy or hysterectomy without any morcellation bag

laparoscopic myomectomy or hysterectomy without any morcellation bag

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Women aged 18 years or more
* Laparoscopic myomectomy or laparoscopic subtotal hysterectomy
* Informed and signed consent

Exclusion Criteria

* Interview revealing disorder entailing unacceptable risk of postoperative complications: coagulation disorder, immune system disorder, evolutive disease, etc.
* Preoperative risk of leiomyosarcoma or pelvic carcinoma
* Pregnancy or desire of pregnancy during the study period
* Uterus or myomas weight above 1.000 g
* Inability to understand information provided
* Not covered by a national health insurance scheme, prisoner or under administrative supervision
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gautier CHENE, MD

Role: PRINCIPAL_INVESTIGATOR

Gynaecology Department, Hôpital Femme Mère Enfant, HCL

Locations

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Gynaecology Department, Hôpital Femme Mère Enfant

Bron, , France

Site Status

Countries

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France

References

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Bensouda-Miguet C, Nohuz E, Cerruto E, Buenerd A, Nadaud B, Moret S, Chene G. Inbag Morcellation Applied to the Laparoscopic Surgery of Leiomyoma: A Randomized Controlled Trial. Biomed Res Int. 2021 May 26;2021:6611448. doi: 10.1155/2021/6611448. eCollection 2021.

Reference Type BACKGROUND
PMID: 34136570 (View on PubMed)

Other Identifiers

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2017-A01773-50

Identifier Type: OTHER

Identifier Source: secondary_id

69HCL16_0714

Identifier Type: -

Identifier Source: org_study_id

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