Online Cognitive Control Training for Remitted Depressed Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-01

Study Completion Date

2019-03-13

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study evaluates the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients. Half of the participants will receive a cognitive control training, while the other half will receive a low cognitive load training that acts as an active control condition.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Cognitive Control Training for Remitted Depressed Patients

NCT02407652

Major Depression in Remission

COMPLETED NA

Effects of Booster Sessions on Depression Vulnerability Following Cognitive Control Training

NCT05557760

Major Depression in Remission

RECRUITING NA

RCT for Electroconvulsive Treatment Followed by Cognitive Control Training

NCT05683028

Depressive Episode Electroconvulsive Therapy Cognitive Remediation

COMPLETED NA

Effects of Online Cognitive Control Training on Rumination and Depressive Symptoms

NCT03011216

Depression Rumination - Thoughts

COMPLETED NA

The Effect of Attention Training on Symptoms and Emotion Regulation in Depressive Patients

NCT05269433

Depression

ENROLLING_BY_INVITATION NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Prospective studies have linked impaired cognitive control to increased cognitive vulnerability for future depression. Importantly, experimental studies indicate that cognitive control training can be used to reduce rumination and depressive symptomatology in MDD (major depressive disorder) and RMD (remitted depressed) samples. Provided that remitted depressed patients form a high-risk group for developing future depressive episodes, the current study will explore whether an internet-delivered cognitive control training can be used to reduce vulnerability for future depression in remitted depressed patients.

A computer training, consisting of 10 sessions of 15 minutes each, will be administered to participants, which are remitted depressed patients. This training can either be a cognitive control training, using an adaptive paced auditory serial addition task, or an active control training, with a low cognitive load task.

Dependent variables will be assessed pre- and post-training, as well as 3 and 6 months after the training, and consist of depressive symptomatology, related variables and cognitive control measures.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Major Depression in Remission

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Between subjects-design with two training conditions. The training condition is the only difference between the two groups during the study.

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Cognitive Control Training

A cognitive control training, consisting of 10 sessions of 15 minutes each, will be administered. The task in this training is an adaptive paced auditory serial addition task, where participants need to click on the sum of the last two heard digits.

Group Type EXPERIMENTAL

Cognitive control training

Intervention Type BEHAVIORAL

10 sessions of an adaptive paced auditory serial addition task, each lasting 15 minutes, over the course of two weeks.

Active Control Training

An active control training, consisting of 10 sessions of 15 minutes each, will be administered. The task in this training is an adaptive low load cognitive task, where participants need to click on the last heard digit.

Group Type ACTIVE_COMPARATOR

Active control training

Intervention Type BEHAVIORAL

10 sessions of an low cognitive load task, each lasting 15 minutes, over the course of two weeks.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Cognitive control training

10 sessions of an adaptive paced auditory serial addition task, each lasting 15 minutes, over the course of two weeks.

Intervention Type BEHAVIORAL

Active control training

10 sessions of an low cognitive load task, each lasting 15 minutes, over the course of two weeks.

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* History of ≥ 1 depressive episodes (major or bipolar)
* Currently in stable full or partial remission (≥ 3 months)

Exclusion Criteria

* Major depressive disorder (current or less than 3 months in remission)
* Bipolar disorder (current or less than 3 months in remission)
* Psychotic disorder (current and/or previous)
* Neurological impairments (current and/or previous)
* Excessive substance abuse (current and/or previous)
* No ongoing psychotherapeutic treatment (maintenance treatment is allowed, but with a frequency of less than once every three weeks)
* Use of antidepressant medication is allowed if kept at a constant level

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes