Computerized Cognitive Training in Young Adults With Depression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-11

Study Completion Date

2023-03-31

Brief Summary

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The purpose of the study is to examine the benefits and mechanism of action of computerized cognitive training (CCT) on mood, neuropsychological deficits, everyday functioning, and brain activity among young adults with a range of depressive symptoms.

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Detailed Description

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Conditions

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Depressive Symptoms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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EF/PS CCT

This group will complete EF/PS (executive functioning/processing speed) computerized cognitive training (CCT) which includes games specifically focused on executive function \& processing speed.

Group Type EXPERIMENTAL

Computerized Cognitive Training

Intervention Type OTHER

Participants will complete 8 weeks of computerized cognitive training through the Peak platform on mobile devices.

Verbal CCT

This group will complete verbal-focused computerized cognitive training.

Group Type ACTIVE_COMPARATOR

Computerized Cognitive Training

Intervention Type OTHER

Participants will complete 8 weeks of computerized cognitive training through the Peak platform on mobile devices.

Waitlist Control

This group will not receive cognitive training during study participation.

Group Type PLACEBO_COMPARATOR

Control

Intervention Type OTHER

This group will not receive computerized cognitive training.

Interventions

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Computerized Cognitive Training

Participants will complete 8 weeks of computerized cognitive training through the Peak platform on mobile devices.

Intervention Type OTHER

Control

This group will not receive computerized cognitive training.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Age 18-29.
2. Current diagnosis of MDD/persistent depressive disorder or HDRS greater than or equal to 12. 3. Daily access to smartphone or tablet with internet connection for the study duration.

4\. Willing and able to complete MRI, mood, and neuropsychological testing. 5. IQ \> 85.

Exclusion Criteria

1. Lacks English-speaking ability as determined by self-report and clinical evaluation.
2. Evidence of schizophrenia, schizoaffective disorder, psychosis, bipolar I and II disorder.
3. Active suicidal ideation, intent, or plan, or past attempt within 1 year.
4. Severe depression (HDRS \> 30).
5. Neurological disorder (epilepsy, multiple sclerosis, traumatic brain injury, clinical stroke).
6. Use of medications known to have negative impact on cognition (benzodiazepines and lorazepam equivalents \> 1mg daily, narcotics, anticholinergics).
7. History of alcohol or drug abuse or dependence within past year.
8. Acute, severe, unstable medical illness. For cancer, acutely ill patients (including those with metastases) are excluded, but past history of successfully treated cancer does not result in exclusion.
9. Regular online brain training or regular player of non-fluency verbal games, defined as doing these procedures at a frequency of twice weekly or greater during the year prior to screening.

Minimum Eligible Age

18 Years

Maximum Eligible Age

29 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes