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Cognitive Control Training for Remitted Depressed Patients

NCT ID: NCT02407652

Last Updated: 2015-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-12-31

Study Completion Date

2015-10-31

Brief Summary

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The purpose of this study is to explore the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.

Detailed Description

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Prospective studies have linked impaired cognitive control to increased cognitive vulnerability for future depression. Importantly, experimental studies indicate that cognitive control training can be used to reduce rumination and depressive symptomatology in MDD samples. Furthermore, studies exploring the potential of cognitive control training in at-risk undergraduate students indicate that cognitive control training has beneficial effects on rumination, an important vulnerability factor for depression. Provided that remitted depressed patients form a high-risk group for developing future depressive episodes, the current study will explore whether internet-delivered cognitive control training can be used to reduce vulnerability for future depression in remitted depressed patients. The investigators will explore effects on depressive symptomatology, (mal-)adaptive emotion regulation (directly following training and at 3 months follow-up), and indices of functioning (at 3 months follow-up).

Conditions

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Major Depression in Remission

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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cognitive control training

internet-delivered, 2 weeks

Group Type EXPERIMENTAL

Cognitive Control Training

Intervention Type BEHAVIORAL

10 adaptive Paced Auditory Serial Addition Task (PASAT) sessions, 400 trials each

low cognitive load training

internet-delivered, 2 weeks

Group Type ACTIVE_COMPARATOR

Low Cognitive Load Training

Intervention Type BEHAVIORAL

10 low cognitive load sessions, 400 trials each

Interventions

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Cognitive Control Training

10 adaptive Paced Auditory Serial Addition Task (PASAT) sessions, 400 trials each

Intervention Type BEHAVIORAL

Low Cognitive Load Training

10 low cognitive load sessions, 400 trials each

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* History of ≥ 1 depressive episode(s)
* Currently in stable full or partial remission (≥ 6 months)

Exclusion Criteria

* Major depressive disorder (MDD; current)
* Bipolar disorder (current and/or previous)
* Psychotic disorder (current and/or previous)
* Neurological impairments (current and/or previous)
* Excessive substance abuse (current and/or previous)
* No other comorbid disorders (current)
* No ongoing psychotherapeutic treatment (maintenance treatment is allowed, but with a frequency less than once / 3 weeks)
* Use of antidepressant medication is allowed if kept at a constant level
Minimum Eligible Age

23 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Ghent

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ernst Koster, PhD

Role: PRINCIPAL_INVESTIGATOR

University Ghent

Locations

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Ghent University

Ghent, Oost-Vlaanderen, Belgium

Site Status

Countries

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Belgium

References

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Hoorelbeke K, Koster EHW. Internet-delivered cognitive control training as a preventive intervention for remitted depressed patients: Evidence from a double-blind randomized controlled trial study. J Consult Clin Psychol. 2017 Feb;85(2):135-146. doi: 10.1037/ccp0000128. Epub 2016 Jun 30.

Reference Type DERIVED
PMID: 27362792 (View on PubMed)

Hoorelbeke K, Faelens L, Behiels J, Koster EH. Internet-delivered cognitive control training as a preventive intervention for remitted depressed patients: Protocol for a randomized controlled trial. BMC Psychiatry. 2015 Jun 9;15:125. doi: 10.1186/s12888-015-0511-0.

Reference Type DERIVED
PMID: 26055122 (View on PubMed)

Other Identifiers

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B/13808/01-CCT-003

Identifier Type: -

Identifier Source: org_study_id