Effects of Online Cognitive Control Training on Rumination and Depressive Symptoms

NCT ID: NCT03011216

Last Updated: 2022-08-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 65 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-07-01
• Study Completion Date: 2021-02-01

Brief Summary

The present study examines whether a computerized cognitive control training as compared to a placebo (fake) training will reduce the frequency of depressive rumination in depressed individuals. Rumination has been identified as a major risk factor for the onset and recurrence of depressive episodes and it has been suggested that it is linked to deficits in cognitive control functions. It is thus expected that training cognitive control will reduce the frequency of rumination as well as ameliorate its detrimental effect on negative mood states.

Detailed Description

Rumination has been shown to intensify dysphoric mood and is one of the best researched risk factors for the onset and recurrence of depressive episodes. Accumulating evidence suggests that the tendency to ruminate is linked to impairments in cognitive control functions, especially to problems discarding no longer relevant negative material from working memory (=working memory updating).

The aim of the present study is to examine whether training to update emotional material in working memory will have an effect on the frequency of using rumination as well as on the impact of rumination on mood in the daily lives of clinically depressed participants. Participants will be randomly assigned to 10 sessions of either online cognitive control training or an online placebo condition. The ability to update emotional material in working memory will be assessed pre and post training by two computer tasks (close and far transfer tasks). The effects of the training on daily rumination and the dynamics between daily mood and rumination will be assessed pre- and post-training, as well as at 3-months follow-up using ambulatory assessment (via smartphone app). It is expected that individuals in the training as compared to the placebo group will show a greater reduction in rumination frequency as well as a reduction in the negative impact of rumination on mood.

Conditions

Depression; Rumination - Thoughts

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Adaptive emotional cognitive control training

Adaptive emotional n-back task: On each trial of this task, participants are presented with an emotional facial expression. Participants have to indicate whether the emotion presented in the current trial is the same as n trials back. In order to train participants at their individual ability level, the n-level varies by trial block based on participants' performance on the previous block.

The adaptive emotional n-back task is assumed to train the ability to continuously update emotional material in working memory.

Group Type: EXPERIMENTAL

Adaptive emotional cognitive control training

Intervention Type: BEHAVIORAL

Is supposed to train ability to continuously update emotional material in working memory.

Placebo training

Adaptive non-emotional feature match task: On each trial of this task, participants are presented with two panels containing 8-12 shapes each. Participants are asked to compare the two panels and decide whether or not they are identical. The panels contain a minimum of 8 shapes and a maximum of 12 shapes, depending on participants' performance on the previous block.

The adaptive non-emotional feature match task is assumed to train the speed of responding (involving processes like visual search and concentration). It does not trait working memory updating.

Group Type: ACTIVE_COMPARATOR

Adaptive non-emotional feature match task

Intervention Type: BEHAVIORAL

Does not train updating of working memory content; may train reaction time speed, visual search, or concentration abilities.

Interventions

Adaptive emotional cognitive control training

Is supposed to train ability to continuously update emotional material in working memory.

Intervention Type: BEHAVIORAL

Adaptive non-emotional feature match task

Does not train updating of working memory content; may train reaction time speed, visual search, or concentration abilities.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) criteria for a current major depressive episode
• 18-65 years of age
• German native language (due to verbal task requirements)

Exclusion Criteria

• life time diagnosis of any bipolar or psychotic disorder, or substance dependence
• substance use disorder within past 12 months
• current obsessive-compulsive disorder (OCD) or borderline personality disorder (BPS)
• reporting severe underweight (BMI<18), any neurological disease, severe head injury (e.g. severe concussion), or any brain damage (e.g. due to stroke)
• concurrent psychotherapy during the duration of the study

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Stuttgart

OTHER

Sponsor Role: collaborator

University Ghent

OTHER

Sponsor Role: collaborator

Freie Universität Berlin

OTHER

Sponsor Role: lead

Responsible Party

Ulrike Zetsche

Dr. rer. nat.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ulrike Zetsche, Dr.

Role: PRINCIPAL_INVESTIGATOR

Freie Universität Berlin

Locations

Freie Universität Berlin

Berlin, , Germany

Countries

Germany

Other Identifiers

ZE 1029/3-1

Identifier Type: -

Identifier Source: org_study_id