Evaluation of Two Resin Composites and Two Adhesives for a Novel Restorative Protocol to Treat Cervical Lesions

NCT ID: NCT03215615

Last Updated: 2019-06-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-11-30

Study Completion Date

2019-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Non-carious cervical lesion is frequently associated with gingival recession, resulting in a combined lesion that has a different treatment prognosis when the two lesions appear alone. The literature presents few studies that propose a multidisciplinary approach (restorative and root coverage surgery procedures) to optimize the treatment of this combined lesion. The previously proposed approaches and materials have limitations and an optimal clinical protocol has not been established yet. Thus the aim of this study is to evaluate a novel multidisciplinary protocol with two resin composites and two different adhesive systems through a randomized clinical trial and laboratory studies. 120 combined lesions will be randomly assigned to one of the following groups: NP + TE (n = 30) - Partial restoration of cervical lesions with nanofilled composite and total-etch adhesive system and periodontal surgery for root coverage, NP + UA (n = 30) - partial restoration of cervical lesions with nanofilled composite and self-etching adhesive system and periodontal surgery for root coverage, MH + TE (n = 30) - partial restoration of cervical lesions with microhybrid composite and total-etch adhesive system and periodontal surgery for root coverage, MH + UA (n = 30) - partial restoration of cervical lesions with microhybrid composite and self-etching adhesive system and periodontal surgery for root coverage. Restorations will be assessed using the USPHS criteria after one week, six months and twelve months.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Dental Abrasion Gingival Recession Composite Resins

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group NF + TE

Nanofilled Composite - Filtek Z350 XT® - 3M ESPE (NF) + Total Etch adhesive - Adper Single Bond 2® - 3M ESPE (TE) adhesive: combined lesions will be treated with partial restoration with nanofilled resin composite and total-etch adhesive system (two step). Subsequently, periodontal surgery will be performed for root coverage.

Group Type ACTIVE_COMPARATOR

Periodontal surgery

Intervention Type PROCEDURE

Coronally advanced flap for root coverage

Total Etch adhesive

Intervention Type PROCEDURE

Total-etch adhesive system (two step)

Nanofilled Composite

Intervention Type PROCEDURE

Partial nanofilled-resin composite restoration

Group NF + UA

Nanofilled Composite - Filtek Z350 XT® - 3M ESPE (NF) + Universal Adhesive - Single Bond Universal® - 3M ESPE (UA): combined lesions will be treated with partial restoration with nanofilled resin composite and one-step self-etching adhesive system. Subsequently, periodontal surgery will be performed for root coverage.

Group Type ACTIVE_COMPARATOR

Periodontal surgery

Intervention Type PROCEDURE

Coronally advanced flap for root coverage

Universal Adhesive

Intervention Type PROCEDURE

One-step self-etching adhesive system

Nanofilled Composite

Intervention Type PROCEDURE

Partial nanofilled-resin composite restoration

Group MH + TE

Micro-Hybrid Composite - Charisma Classic® - Heraeus Kulzer (MH) + Total Etch adhesive - Adper Single Bond 2® - 3M ESPE (TE) adhesive: combined lesions will be treated with partial restoration with micro-hybrid resin composite and total-etch adhesive system (two step). Subsequently, periodontal surgery will be performed for root coverage.

Group Type ACTIVE_COMPARATOR

Periodontal surgery

Intervention Type PROCEDURE

Coronally advanced flap for root coverage

Total Etch adhesive

Intervention Type PROCEDURE

Total-etch adhesive system (two step)

Micro-Hybrid Composite

Intervention Type PROCEDURE

Partial micro-hybrid composite restoration

Group MH + UA

Micro-Hybrid Composite - Charisma Classic® - Heraeus Kulzer (MH) + Universal Adhesive - Single Bond Universal® - 3M ESPE (UA): combined lesions will be treated with partial restoration with micro-hybrid resin composite and one-step self-etching adhesive system. Subsequently, periodontal surgery will be performed for root coverage.

Group Type ACTIVE_COMPARATOR

Periodontal surgery

Intervention Type PROCEDURE

Coronally advanced flap for root coverage

Universal Adhesive

Intervention Type PROCEDURE

One-step self-etching adhesive system

Micro-Hybrid Composite

Intervention Type PROCEDURE

Partial micro-hybrid composite restoration

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Periodontal surgery

Coronally advanced flap for root coverage

Intervention Type PROCEDURE

Total Etch adhesive

Total-etch adhesive system (two step)

Intervention Type PROCEDURE

Universal Adhesive

One-step self-etching adhesive system

Intervention Type PROCEDURE

Nanofilled Composite

Partial nanofilled-resin composite restoration

Intervention Type PROCEDURE

Micro-Hybrid Composite

Partial micro-hybrid composite restoration

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Individuals presenting one or more combined defect, i.e. a NCCL classified as B+ (Pini-Prato et al., 2010): presenting more than 1mm in depth, affecting dental crown and root associated with Miller's class I or II gingival recession in canines or premolars with pulp vitality;
* Healthy patients (systemically and periodontally), 18 years old, with at least 20 teeth in occlusion;
* Plaque index ≤ 20% (Ainamo \& Bay, 1975);
* NCCL cavo-surface margin without involvement of more than 50% of enamel;
* In tooth included in the study and the adjacent elements of the following must be observed: probing depth less than 3 mm; do not show bleeding on probing (periodontal health) and no insertion loss in the proximal and palatal areas; Provide formal consent to participate in research, after the explanation of the risks and benefits by an individual not involved in it (Resolution #196 October 1996 and the Code of Dental Professional Ethics - C.F.O. - 179/93).

Exclusion Criteria

* NCCL previously restored;
* Presence of caries;
* Patients with periodontitis;
* Patients with bruxism or teeth clenching;
* Patients with orthodontic treatment in progress;
* Pregnant patients or smokers;
* Patients with systemic problems (cardiovascular, blood dyscrasias, immunodeficiency, diabetes and others), which contraindicate the surgical procedure; Previous periodontal surgery in the area of interest of the present study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Universidade Estadual Paulista Júlio de Mesquita Filho

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Eduardo Bresciani

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Eduardo Bresciani, PhD

Role: PRINCIPAL_INVESTIGATOR

Universidade Estadual Paulista Júlio de Mesquita Filho

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

UEPJMF

São José dos Campos, São Paulo, Brazil

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Brazil

References

Explore related publications, articles, or registry entries linked to this study.

Mathias-Santamaria IF, Santamaria MP, Silveira CA, Martinho FC, de Melo MAS, De Marco AC, Augusto MG, de Andrade GS, Roulet JF, Bresciani E. Evaluation of a novel restorative protocol to treat non-carious cervical lesion associated with gingival recession: a 2-year follow-up randomized clinical trial. Clin Oral Investig. 2023 Apr;27(4):1781-1792. doi: 10.1007/s00784-022-04806-1. Epub 2022 Dec 3.

Reference Type DERIVED
PMID: 36462038 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

56450116.9.0000.0077

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.