Dynamic Arterial Elastance as a Predictor of Arterial Blood Pressure Response to Fluid Administration in Septic Patients

NCT ID: NCT03179215

Last Updated: 2018-07-17

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 58 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-07-01
• Study Completion Date: 2018-06-30

Brief Summary

Correction of arterial hypotension is essential for adequate cellular metabolism. maintaining MAP above a minimum level has been recommended in order to prevent further tissue hypoperfusion and organ dysfunction.Functional assessment of arterial load by dynamic arterial elastance (Eadyn), has recently been shown to predict the arterial pressure response to volume expansion (VE) in hypotensive, preload-dependent septic patients.

Detailed Description

After approval from the ethics and research committee of Faculty of Medicine, Cairo University, an informed consent will be obtained from each patient's next of kin. Arteial cathter will be inserted in radial artery and connected through an arterial line to invasive arterial blood pressure monitor. Electrical Cardiometry will be attached to patient through the placement of four skin sensors on the neck and left side of the thorax12. A set of hemodynamic measurements will be obtained at baseline and after infusing a fluid challenge (FC) of 150-250 ml normal saline over 5-10 minutes.Fluid-responders are patients with a SV increase ≥10% after fluid challenge (FC).

Conditions

Sepsis

Study Design

• Observational Model Type: CASE_CROSSOVER
• Study Time Perspective: PROSPECTIVE

Interventions

fluid challange

A set of hemodynamic measurements will be obtained at baseline and after infusing a fluid challenge (FC) of 150-250 ml normal saline over 5-10 minutes.Fluid-responders are patients with a SV increase ≥10% after fluid challenge

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Adult patients (more than 18 years).
• Sepsis as a cause of admission.

Exclusion Criteria

• • Patients younger than 18 years of age.

• Pregnant females.
• Trauma as a cause of intensive care unit (ICU)admission.
• Known medical history of vasodilator therapy.
• Cardiac arrhythmias.
• Any absolute contraindication for fluid administration such as congestive heart failure, pulmonary edema and/or fluid overload

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

soudy salah hammad

Anesthesia, ICU and pain management assistant lecturer ,Aswan University

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

ahmed m mukhtar, proffesor

Role: PRINCIPAL_INVESTIGATOR

Cairo University

Locations

Trauma & Surgical ICU. New Emergency Hospital (185 Hospital)

Cairo, , Egypt

Countries

Egypt

References

Garcia MI, Romero MG, Cano AG, Aya HD, Rhodes A, Grounds RM, Cecconi M. Dynamic arterial elastance as a predictor of arterial pressure response to fluid administration: a validation study. Crit Care. 2014 Nov 19;18(6):626. doi: 10.1186/s13054-014-0626-6.

Reference Type: BACKGROUND

PMID: 25407570 (View on PubMed)

Cecconi M, Monge Garcia MI, Gracia Romero M, Mellinghoff J, Caliandro F, Grounds RM, Rhodes A. The use of pulse pressure variation and stroke volume variation in spontaneously breathing patients to assess dynamic arterial elastance and to predict arterial pressure response to fluid administration. Anesth Analg. 2015 Jan;120(1):76-84. doi: 10.1213/ANE.0000000000000442.

Reference Type: BACKGROUND

PMID: 25230102 (View on PubMed)

Other Identifiers

N-35 -2017

Identifier Type: -

Identifier Source: org_study_id