MedDataX Logo

Midodrine is Effective in Management of Intradialytic Hypotension Among Critically-ill Patients With Acute Kidney Injury

NCT ID: NCT03431194

Last Updated: 2022-08-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-01

Study Completion Date

2017-04-06

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this randomized trial was to assess the efficacy of oral midodrine tablets for the management of intradialytic hypotension among critically ill patients with acute kidney injury.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Midodrine for the Treatment of Refractory Hypotension

NCT01531959

Hypotension Critical Illness
COMPLETED PHASE3

Hydrochloorthiazide and Hypernatriaemie

NCT01974739

Hypernatraemia
COMPLETED NA

Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.

NCT03145935

Hypovolemia Diuretic Toxicity Fluid Overload
UNKNOWN

Descriptive Study of Cardiac Output During Rehydration With Recombinant Human Hyaluronidase in Pediatrics

NCT01139294

Dehydration Cardiac Output Pediatrics
COMPLETED PHASE4

Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU

NCT06547892

Critical Illness
RECRUITING PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

In This open -label study, patients in ICU with acute kidney injury are randomized to either midodrine tablets or placebo. the number of intradialytic episodes and both systolic and diastolic blood pressure between both groups are compared. Mortality and adverse effects are monitored and compared as well.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Kidney Injury

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

midodrine group

Patients will receive midodrine tablets

Group Type ACTIVE_COMPARATOR

midodrine

Intervention Type DRUG

oral midodrine tablets 5 mg

placebo group

Patients receive sugary oral tablets therapy

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

midodrine

oral midodrine tablets 5 mg

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* ICU patients
* acute kidney injury
* age above 18 years
* documented hypotension during dialysis

Exclusion Criteria

* packed red blood cells transfusion
* intravenous inotropes
* alteration of blood pressure medications
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

New Jeddah Clinic Hospital

INDUSTRY

Sponsor Role collaborator

Benha University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Mahmoud Hamada imam

Lecturer of Internal Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

BN-14716

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Hemodynamic Optimization By Non-Invasive Determination Of Cardiac Output In Critically Ill Patients
NCT01309724 COMPLETED NA
Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients
NCT00298454 TERMINATED PHASE3
Tailored Hydration Based on Bioimpedance Analysis for Prevention of Contrast Induced Acute Kidney Injury
NCT04215042 UNKNOWN NA
Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study
NCT01393782 COMPLETED PHASE1
Vasoactive Drugs in Intensive Care Unit
NCT02118467 RECRUITING PHASE4
An Open Label Trial to Decrease Signs and Symptoms of Orthostatic Hypotension Using Midodrine or Intravenous Fluid Bolus in Patients Following Total Hip Arthroplasty
NCT02154243 TERMINATED NA
The Furosemide Stress Test, Electrolytes Response and Renal Index in Critically Ill Patients
NCT04215419 COMPLETED
Automated Abdominal Binder for Orthostatic Hypotension
NCT03482297 RECRUITING PHASE1/PHASE2
Low Dose Vasopressin in Traumatic Shock
NCT00420407 TERMINATED EARLY_PHASE1
0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Critically Ill Children
NCT01301274 COMPLETED NA
Non-interventional Follow-up Versus Fluid Bolus in RESPONSE to Oliguria in the Critically Ill
NCT02860572 COMPLETED NA
Methoxyflurane and Fentanyl in LBNP
NCT04641949 COMPLETED PHASE4
Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury
NCT00113685 COMPLETED NA
Response of Pulse Pressure Variation in PA Catheter Tracing to IV Fluid Bolus in the ICU
NCT02419404 COMPLETED
Mannitol - Potential Role in Hemodialysis Initiation for Reduction of Intra-dialytic Hypotension
NCT01520207 COMPLETED PHASE2
Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill Adults
NCT05933642 UNKNOWN PHASE2/PHASE3
Dynamic Arterial Elastance as a Predictor of Arterial Blood Pressure Response to Fluid Administration in Septic Patients
NCT03179215 COMPLETED
Dopamine and Norepinephrine Infusion With Restricted Hydration
NCT03780686 COMPLETED NA
AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock
NCT01611935 COMPLETED PHASE2
The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients
NCT01072071 UNKNOWN NA
Small Volume Fluid Challenge as a Predictor of Fluid Responsiveness in Patients With Circulatory Failure
NCT03622099 COMPLETED
Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis
NCT06464510 RECRUITING PHASE3
Impact of Starting Dose of Vasopressor on Hemodynamic Response in Shock
NCT06481839 NOT_YET_RECRUITING NA
Midodrine Versus Albumin for Prevention of Paracentesis Induced Circulatory Disturbance
NCT05240391 COMPLETED PHASE3
Efficacy and Safety of a Citrate-based Anticoagulation With Calcium-free Phosphate-containing Fluid in Renal Replacement Therapy
NCT04215965 UNKNOWN PHASE4