Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

PHASE2/PHASE3

Total Enrollment

132 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-02

Study Completion Date

2023-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of this RCT is to compare the effectiveness of aminophylline and furosemide combination vs furosemide alone in producing effective diuresis in critically ill adults in ICU. ICU patients with the need of improved diuresis will be recruited and given either infusion of aminophylline and furosemide combination or furosemide alone, and their hourly urine output will be monitored to compare their effectiveness.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Furosemide Stress Test, Electrolytes Response and Renal Index in Critically Ill Patients

NCT04215419

Acute Kidney Injury

COMPLETED

Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients

NCT00298454

Renal Failure Critically Ill

TERMINATED PHASE3

The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients

NCT01072071

Intra-Abdominal Hypertension

UNKNOWN NA

Effect of Fluid Deresuscitation With Central Venous Pressure Target 0-4 mmHg in Septic Shock Patients

NCT04156451

Septic Shock

COMPLETED NA

Furosemide Stress Test to Predict Successful Liberation From RRT

NCT05612490

Acute Kidney Injury

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Kidney Injury

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

double blind, randomised, controlled trial

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Recruited patient randomised into intervention vs control group by non clinical personnel, trial drugs dilution by research assistant, drug administered to patient by staff nurses, data collection by independent group

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Treatment group

Intravenous (IV) infusion of (aminophylline 150mg and frusemide 120mg diluted to 50ml NS), IV load 10ml over 60 minutes, followed by IV infusion of 4 ml/hour

Group Type ACTIVE_COMPARATOR

Aminophylline

Intervention Type DRUG

aminophylline 150mg

Frusemide

Intervention Type DRUG

frusemide 120mg

Control group

IV infusions of furosemide (120mg diluted to 50ml NS), IV load 10ml over 60 minutes, followed by IV infusion of 4 ml/hour

Group Type ACTIVE_COMPARATOR

Frusemide

Intervention Type DRUG

frusemide 120mg

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Aminophylline

aminophylline 150mg

Intervention Type DRUG

Frusemide

frusemide 120mg

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Lasix

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients aged 18 years old and above who are admitted to the ICU of UMMC during the study period
* Oliguric patients, with the need for improved diuresis at clinician discretion - defined as urine output \<0.5ml/kg/hour

Exclusion Criteria

* Patient refusal for participation of study
* Patients with known hypersensitivity reaction to aminophylline or furosemide
* Patients with history of tachyarrhythmias, seizures, aspartate aminotransferase or alanine aminotransferase \> 3 times normal, or hypothyroidism.

Patient with existing peptic ulcer disease or coagulopathy with INR \> 1.5

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No