Influence of Deep Versus Moderate Neuromuscular Blockade During General Anesthesia on 30-day Readmission Rates

NCT ID: NCT03174223

Last Updated: 2019-09-17

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 460 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-06-01
• Study Completion Date: 2018-07-01

Brief Summary

Deep neuromuscular block (NMB) has shown to produce superior surgical conditions during various abdominal and non abdominal surgeries. It is however unknown if the application of deep NMB leads to favourable outcome, such as lower rate of postoperative complications in general and surgical infections in specific and ultimately lower readmission rates. In the leiden university medical center, deep NMB is routinely applied for a variety of procedures, most notably laparoscopic abdominal and retroperitoneal surgery, eye surgery and neuro radiologic intervention surgery, since 2014. This retrospective study intends to investigate whether the application of deep NMB for these procedures affects patient outcome and readmission rates.

Conditions

Postoperative Complications; Postoperative Wound Infection; Pneumonia

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: RETROSPECTIVE

Study Groups

Deep neuromuscular block

patients received a continuous rocuronium dose to maintain a depth of neuromuscular block of 1-2 twitches post tetanic count

deep neuromuscular block

Intervention Type: DRUG

a continuous dosing of rocuronium is used to achieve neuromuscular block of 1-2 twitches post tetanic count

moderate neuromuscular block

patients received neuromuscular block aimed at \> 0 twitches train of four

No interventions assigned to this group

Interventions

deep neuromuscular block

a continuous dosing of rocuronium is used to achieve neuromuscular block of 1-2 twitches post tetanic count

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• deep neuromuscular block
• moderate neuromuscular block
• general anesthesia
• complete anesthesia chart

Exclusion Criteria

• incomplete anesthesia chart
• missing data regarding postoperative complications or readmission

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role: collaborator

Leiden University Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Albert Dahan

Clinical Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Leiden University Medical Center

Leiden, , Netherlands

Countries

Netherlands

Other Identifiers

p17.031

Identifier Type: -

Identifier Source: org_study_id