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Dose for Deep Neuromuscular Blockade Deciding Factor of Neuromuscular Blocker Dose for Deep Neuromuscular Blockade

NCT ID: NCT04688268

Last Updated: 2020-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-10

Study Completion Date

2021-07-30

Brief Summary

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Find out the deciding factor(total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) of neuromuscular blocker dose for deep neuromuscular blockade.

Detailed Description

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Before the surgery, total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index were measured by height and weight and skeletal muscle mass and body fat were measured by Bioelectrical impedance analysis (InbodyH20N). Find the highest correlation between the 8 factors (total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) and the amount of rocuronium administered to deep neuromuscular blockade.

Conditions

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Laparoscopic Surgery

Keywords

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laparoscopic surgery deep neuromuscular blockade

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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deep neuromuscular blockade

patients who underwent surgery with deep neuromuscular blockade

deep neuromuscular blockade

Intervention Type DRUG

Train of Four=0/4, Post tetanic count 1-2

Interventions

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deep neuromuscular blockade

Train of Four=0/4, Post tetanic count 1-2

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* patients aged 20-80 and American Society of Anesthesiology Physical Grade (ASA) I-II, who undergo laparoscopic surgery for at least 2 hours under general anesthesia

Exclusion Criteria

* kidney disease (GFR\<60)
* allergy to study drugs
* decline participation
* side effect of propofol and remifentanil
* when anesthesia does not maintain the level of alertness (BIS) below 60 even when the anesthetic dose is increased, or when hemodynamic instability such as bradycardia and hypotension appears
Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Bundang Hospital

OTHER

Sponsor Role lead

Responsible Party

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JiWon Han

principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Jiwon Han, Dr

Role: CONTACT

Phone: 82-10-3447-1988

Email: [email protected]

Ah-young Oh, Dr

Role: CONTACT

Phone: 82-31-787-7506

Email: [email protected]

References

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Choi YJ, Hee Kim Y, Bae GE, Yu JH, Yoon SZ, Kang HW, Lee KS, Kim JH, Lee YS. Relationship between the muscle relaxation effect and body muscle mass measured using bioelectrical impedance analysis: A nonrandomized controlled trial. J Int Med Res. 2019 Apr;47(4):1521-1532. doi: 10.1177/0300060518822197. Epub 2019 Feb 5.

Reference Type BACKGROUND
PMID: 30719949 (View on PubMed)

Other Identifiers

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B-2008/633-302

Identifier Type: -

Identifier Source: org_study_id