Role of Femoral Nerve Block on Prevention of Postoperative Deep Venous Thromboembolism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-09-30

Study Completion Date

2015-10-31

Brief Summary

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To investigate whether preemptive analgesic of femoral nerve block could prevent deep venous thromboembolism due to inhibiting the excessive release of neutrophil elastase and inflammatory cytokines.

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Detailed Description

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Femoral nerve block is an effective analgesic mode in patients after total knee arthroplasty. In recent studies, there has been shown that a large amount of neutrophil elastase release from neutrophils could induce the development of deep venous thromboembolism and femoral nerve block may reduce the incidence of the development of deep venous thromboembolism. In addition, inflammatory cytokines including interleukin-1(IL-1), IL-6, IL-8 and tumor necrosis factor(TNF) were associated with deep venous thromboembolism. Thus, the investigators hypothesised that preemptive analgesic of femoral nerve block could prevent deep venous thromboembolism due to inhibiting the excessive release of neutrophil elastase and inflammatory cytokines.

Conditions

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Gonarthrosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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femoral nerve block

femoral nerve block will be administered before or after the surgery

Group Type EXPERIMENTAL

femoral nerve block

Intervention Type PROCEDURE

use the nerve stimulator,the femoral nerve block will be administered before or after the surgery

Interventions

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femoral nerve block

use the nerve stimulator,the femoral nerve block will be administered before or after the surgery

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* adult patients scheduled for total knee arthroplasty under general anesthesia

Exclusion Criteria

* ASA physical status Ⅳ-Ⅴ,
* psychiatric illness,
* chronic opioid consumption,
* patient refusal,
* coagulopathy,
* peripheral neurological injury,
* local anesthesia drug allergy,
* preoperative existing deep venous thromboembolism.

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No