High Pressure Balloon vs Cutting Balloon

NCT ID: NCT03145662

Last Updated: 2024-06-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-23

Study Completion Date

2019-03-23

Brief Summary

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Patients suspected of having AV access stenosis will be referred to the Division of Vascular and Endovascular Surgery by the dialysis center. Patients with signs of AV access failure who are found to have significant stenosis (more than 50%) at the venous end of the anastomosis will then be randomized to either high pressure balloon (Conquest) or to a cutting balloon (Boston scientific Balloon). Angiograms will then be performed before and after intervention.

Detailed Description

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Patients suspected of having AV access stenosis will be referred to the Division of Vascular and Endovascular Surgery by the dialysis center. Patients with signs of AV access failure who are found to have significant stenosis (more than 50%) at the venous end of the anastomosis will then be randomized to either high pressure balloon (Conquest) or to a cutting balloon (Boston scientific Balloon). Angiograms will then be performed before and after intervention.

Data will be collected from standard of care visit, including physician visits and ultrasounds. Follow up will be based on the function of the AV access, dialysis center criteria and/or standard of care ultrasound results: including venous pressure of the AV access, difficult cannulation, urea recirculation, and change in character and sound of the AV access (thrill/bruit), which are standard of care assessment at a dialysis center. All patient data sheets will be kept in a study binder and locked in the research room. Randomization will be performed with a computer program.

Conditions

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End Stage Renal Failure on Dialysis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

randomization to either high pressure balloon or cutting balloon
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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high pressure balloon

randomized to have dialysis fistula or AV graft treated with high pressure balloon

Group Type ACTIVE_COMPARATOR

high pressure balloon

Intervention Type DEVICE

high pressure balloon will be used to treat stenosis

cutting balloon

randomized to have dialysis fistula or AV graft treated with cutting balloon

Group Type ACTIVE_COMPARATOR

cutting balloon

Intervention Type DEVICE

cutting balloon will be used to treat stenosis

Interventions

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high pressure balloon

high pressure balloon will be used to treat stenosis

Intervention Type DEVICE

cutting balloon

cutting balloon will be used to treat stenosis

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Age ≥ 18 years of age
2. AV fistula or graft
3. Undergoing weekly hemodialysis
4. Patients must agree to the terms of the study and sign an informed Consent

Exclusion Criteria

1\. Pregnant women
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Toledo Health Science Campus

OTHER

Sponsor Role lead

Responsible Party

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Munier Nazzal, M.S. M.D

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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UTMC

Toledo, Ohio, United States

Site Status

Countries

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United States

Other Identifiers

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HPB vs CB

Identifier Type: -

Identifier Source: org_study_id

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