Angioplasty + SBCV vs. Angioplasty Alone for Femoropopliteal Artery Stenosis

NCT ID: NCT02568293

Last Updated: 2017-02-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2017-10-31

Brief Summary

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The purpose of this study is to compare balloon angioplasty plus SBCV against balloon angioplasty alone for treatment of stenosis within the femoropopliteal artery.

Detailed Description

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This first-in-human study will evaluate the safety and effectiveness of a novel adjunctive therapy, SBCV, used with balloon angioplasty as compared to balloon angioplasty plus a control agent (saline) when used for the treatment of stenosis within the femoropopliteal artery. Effectiveness will be measured by late lumen loss at 24 weeks post treatment as evaluated by an independent, blinded core lab.

Conditions

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Peripheral Arterial Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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SBCV

SBCV is administered to the site immediately post balloon dilation.

Group Type EXPERIMENTAL

SBCV

Intervention Type OTHER

SBCV is a single use, sterile product that acts as a localized physical barrier at the vascular wall.

Control

Saline is used as a control and is delivered immediately post balloon dilation.

Group Type PLACEBO_COMPARATOR

Saline

Intervention Type OTHER

Saline is used as a control.

Interventions

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SBCV

SBCV is a single use, sterile product that acts as a localized physical barrier at the vascular wall.

Intervention Type OTHER

Saline

Saline is used as a control.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Scheduled for balloon angioplasty for stenosis of femoropopliteal lesion(s)
* Rutherford Clinical Category 1-4 (claudication or critical limb ischemia)
* Lesions are ≥70% stenosis by visual estimate
* A patent inflow artery free from significant lesion
* At least one patent native outflow artery to the ankle

Exclusion Criteria

* History of haemorrhagic stroke within 3 months of screening
* History of myocardial infarction, thrombolysis or angina within 2 weeks of screening
* Renal failure or chronic kidney disease
* Severe calcification that renders the lesion undilatable
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Symic Biomedical, Inc.

INDUSTRY

Sponsor Role collaborator

Symic Vascular

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Royal Prince Alfred Hospital

Melbourne, New South Wales, Australia

Site Status

Royal North Shore Hospital

Sydney, New South Wales, Australia

Site Status

Gold Coast University Hospital

Southport, Queensland, Australia

Site Status

Flinders Medical Center

Adelaide, South Australia, Australia

Site Status

Austin Health

Heidelberg, Victoria, Australia

Site Status

The Alfred Hospital

Melbourne, Victoria, Australia

Site Status

Sir Charles Gairdner Hospital

Perth, Western Australia, Australia

Site Status

Auckland City Hospital

Auckland, , New Zealand

Site Status

Countries

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Australia New Zealand

Other Identifiers

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TP-1601

Identifier Type: -

Identifier Source: org_study_id

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