Investigating Accelerated Learning in Healthy Subjects: Trigeminal Nerve Stimulation

Study Results

Results available

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-04

Study Completion Date

2022-01-25

Brief Summary

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The purpose of this study is to investigate whether it is possible to accelerate learning and improve associative memory performance in healthy subjects, by applying transcranial Direct Current Stimulation (tDCS) targeting the trigeminal nerve during a verbal paired-associate learning task

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Detailed Description

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Associative memory refers to remembering the association between two items, such as a face and a name or a word in English and the same word in another language. It is not only important for learning, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer׳s disease. For decades, neuroscientists have investigated associative learning and memory and ways to accelerate and enhance associative learning and memory.

Transcranial Direct Current stimulation (tDCS) is a non-invasive and painless electrical stimulation technique that has demonstrated to accelerate learning and improve memory in some studies. To investigate whether it is possible to accelerate learning and improve associative memory using tDCS, the performance in a Verbal Paired-Associate memory task of 2 groups will be compared. The first group will get active tDCS during the verbal paired-associate learning task. The second group will get sham tDCS during the verbal paired-associate learning task.

Conditions

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Healthy Adults

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

participants will be randomly assigned to one of 2 groups: (1) active tDCS (2) sham tDCS

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Active tDCS

Active transcranial Direct Current Stimulation targeting the trigeminal nerve

Group Type EXPERIMENTAL

Transcranial Direct Current Stimulation- Neuroconn DC Stimulator PLUS

Intervention Type DEVICE

Transcranial Direct Current Stimulation targeting the trigeminal nerve

Sham tDCS

Sham transcranial Direct Current Stimulation targeting the trigeminal nerve

Group Type SHAM_COMPARATOR

Transcranial Direct Current Stimulation- Neuroconn DC Stimulator PLUS

Intervention Type DEVICE

Transcranial Direct Current Stimulation targeting the trigeminal nerve

Interventions

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Transcranial Direct Current Stimulation- Neuroconn DC Stimulator PLUS

Transcranial Direct Current Stimulation targeting the trigeminal nerve

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Native English Speaker

Exclusion Criteria

* History of severe head injuries, epileptic insults, or heart disease.
* Severe psychiatric disorders and severe untreated medical problems
* Acquainted with the foreign language used in the learning task
* Contraindications for tDCS (e.g. pregnant, implanted devices)

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes