Positron Emission Tomography Imaging of Brain Reorganisation of the Central Auditory Cortex in Asymetrical Profound Deaf Patient With a Cochlear Implantation.
NCT ID: NCT03117413
Last Updated: 2025-12-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2017-11-23
2019-03-22
Brief Summary
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Detailed Description
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Patients and controls will undergo a positron emission tomography scan brain imaging session during a simplified voice/non-voice discrimination task. For each tasks and brain imaging sessions, patients will be stimulated either with the non-implanted ear (acoustical stimulation), the cochlear implant (electrical stimulation) and using both modalities in a binaural condition.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Asymmetric hearing loss
Asymmetric hearing loss treated with a cochlear implant will undergo positron emission tomography scan.
Positron emission tomography scan
* Binaural hearing assessments: speech recognition in noise and sound source localization
* Voice perception assessment: voice/non-voice discrimination task, free categorization task
* Positron emission tomography examinations under ecological auditory stimuli (voice/non-voice discrimination task)
Normal hearing subjects
Normal hearing subjects will undergo positron emission tomography scan.
Positron emission tomography scan
* Binaural hearing assessments: speech recognition in noise and sound source localization
* Voice perception assessment: voice/non-voice discrimination task, free categorization task
* Positron emission tomography examinations under ecological auditory stimuli (voice/non-voice discrimination task)
Interventions
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Positron emission tomography scan
* Binaural hearing assessments: speech recognition in noise and sound source localization
* Voice perception assessment: voice/non-voice discrimination task, free categorization task
* Positron emission tomography examinations under ecological auditory stimuli (voice/non-voice discrimination task)
Eligibility Criteria
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Inclusion Criteria
* signature of informed consent
* affiliation to social service.
Exclusion Criteria
* protected subjects
* epilepsy episodes
* psychotropic medication
* pregnancy
18 Years
ALL
Yes
Sponsors
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Centre de recherche Cerveau et Cognition (CERCO)
UNKNOWN
University Hospital, Toulouse
OTHER
Responsible Party
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Principal Investigators
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Mathieu Marx, Pr
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Toulouse
Locations
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CHU de Toulouse - Hôpital Purpan
Toulouse, France, France
CERCO
Toulouse, Midi-Pyrénées, France
Countries
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References
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Karoui C, James C, Barone P, Bakhos D, Marx M, Macherey O. Searching for the Sound of a Cochlear Implant: Evaluation of Different Vocoder Parameters by Cochlear Implant Users With Single-Sided Deafness. Trends Hear. 2019 Jan-Dec;23:2331216519866029. doi: 10.1177/2331216519866029.
Berland A, Collett E, Gaillard P, Guidetti M, Strelnikov K, Cochard N, Barone P, Deguine O. Categorization of everyday sounds by cochlear implanted children. Sci Rep. 2019 Mar 5;9(1):3532. doi: 10.1038/s41598-019-39991-9.
Strelnikov K, Collett E, Gaillard P, Truy E, Deguine O, Marx M, Barone P. Categorisation of natural sounds at different stages of auditory recovery in cochlear implant adult deaf patients. Hear Res. 2018 Sep;367:182-194. doi: 10.1016/j.heares.2018.06.006. Epub 2018 Jun 12.
Other Identifiers
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2016-A01442-49
Identifier Type: OTHER
Identifier Source: secondary_id
RC31/15/7797
Identifier Type: -
Identifier Source: org_study_id
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