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Hearing and Cognition in Aging Adults

NCT ID: NCT06183450

Last Updated: 2023-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

262 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-31

Study Completion Date

2033-01-31

Brief Summary

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This cohort study is expected to provide valuable insights into the complex interplay between auditory and cognitive functions and how they change over time. The results of this study will have important implications for the prevention, diagnosis, and treatment of age-related hearing and cognitive disorders

Detailed Description

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The aim of the study is to identify the early perceptual and cognitive alterations related to age-related hearing loss or presbycusis, establish a correlation between the degree of hearing loss and the deterioration of cognitive functions, and examine the effectiveness of hearing loss management in reversing observed cognitive impairments. This project has the potential to shed light on the importance of early detection of hearing impairments in preventing cognitive decline. The data collected from this cohort, rigorously assessed for both auditory and cognitive functions, could serve as the basis for several high-level scientific investigations.

Conditions

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Presbycusis

Keywords

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presbycusis aging cognitive decline speech in noise sound localisation hearing loss

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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hearing subject

Adult normal hearing subjects, evaluated annually for 5 years,

auditory level

Intervention Type DIAGNOSTIC_TEST

* Evaluation of auditory thresholds through audiometric tests.
* Evaluation of speech comprehension in noise through a vocal audiometry test in noise (FraMatrix).
* Evaluation of spatial auditory behavior and spatial precision using a spatial discrimination test (Minimum Audible Angle) and a static sound localization test in virtual reality.

cognitive level

Intervention Type DIAGNOSTIC_TEST

* Evaluation of attention and short-term memory functions with verbal and non-verbal tasks: Digit Span Test and Reading Span Test.
* Evaluation of inhibition capacities using the Stroop Test.
* Evaluation of executive functions, visual attention, reasoning, and mental arithmetic using the Raven's Matrix test.

quality of life level

Intervention Type DIAGNOSTIC_TEST

\- Evaluation of quality of live level via Speech, Spatial and Qualities of Hearing Scale (SSQ-12) and EuroQol-5D questionnaires.

Interventions

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auditory level

* Evaluation of auditory thresholds through audiometric tests.
* Evaluation of speech comprehension in noise through a vocal audiometry test in noise (FraMatrix).
* Evaluation of spatial auditory behavior and spatial precision using a spatial discrimination test (Minimum Audible Angle) and a static sound localization test in virtual reality.

Intervention Type DIAGNOSTIC_TEST

cognitive level

* Evaluation of attention and short-term memory functions with verbal and non-verbal tasks: Digit Span Test and Reading Span Test.
* Evaluation of inhibition capacities using the Stroop Test.
* Evaluation of executive functions, visual attention, reasoning, and mental arithmetic using the Raven's Matrix test.

Intervention Type DIAGNOSTIC_TEST

quality of life level

\- Evaluation of quality of live level via Speech, Spatial and Qualities of Hearing Scale (SSQ-12) and EuroQol-5D questionnaires.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Normal hearing (Pure Tone Audiometry \< or = 20 dB)
* Residency in one of the three neighborhoods :
* Affiliation with a social security system

Exclusion Criteria

* Individuals under guardianship, trusteeship or curators
* History of neurological pathologies
* Taking of psychotropic medication.
Minimum Eligible Age

45 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Toulouse

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mathieu Marx, Pr

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Toulouse

Locations

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Ecole d'audioprothèse

Cahors, , France

Site Status

Countries

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France

Central Contacts

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Mathieu Marx, Pr

Role: CONTACT

Phone: 05 61 77 77 04

Email: [email protected]

Mariam ALZAHER, Dr

Role: CONTACT

Email: [email protected]

Facility Contacts

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Mariam ALZAHER, Dr

Role: primary

Other Identifiers

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2023-A01415-40

Identifier Type: OTHER

Identifier Source: secondary_id

RC31/22/0252

Identifier Type: -

Identifier Source: org_study_id