Functional Magnetic Resonance Imaging Study of the Central Auditory System After Single Sided Deafness
NCT ID: NCT02534298
Last Updated: 2018-02-15
Study Results
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Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2015-04-30
2016-04-30
Brief Summary
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Detailed Description
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Purpose : Our main objective is to study the relation between the reorganization of the central auditory system, namely the inter hemispheric asymmetry, and the psychophysical deficits in binaural hearing in subjects with SSD.
Abstract : Binaural hearing enables spatial localization of the sound source and improves speech recognition in a competing noise. SSD and asymmetrical hearing loss are common hearing impairments, which affect 0.3 to 1/1000 children. In the adult population, this prevalence increases with age. The impact of SSD and asymmetrical hearing loss on quality of life indices is well established and some reports underline its consequences in children scholarship. Previous neuro-imaging and electro physiological studies highlighted the reduction of normal inter hemispheric asymmetry in subjects with SSD. To the best of our knowledge, there is no report about the relation between the central auditory system reorganization and its behavioural deficits.
The investigators propose to conduct a study which analyzes the relationship between the reduction of inter hemispheric asymmetry and performance in binaural hearing tests. Thus, the auditory plasticity will be studied using functional magnetic resonance imaging and more specifically BOLD variations in auditory temporal cortices. A set of binaural hearing assessments will be performed, including speech recognition in noise and localization abilities. The correlation between the lateralization ratio and binaural measurements (speech reception threshold (SRT) in dichotic hearing, diotic hearing, reverse dichotic hearing) will be estimated. Likewise, the impact of SSD duration on cortical reorganization and binaural tests will be studied.
Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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single sided deafness
single sided deafness and asymmetrical hearing loss patients functional magnetic resonance imaging
functional magnetic resonance imaging
functional magnetic resonance imaging
control group
Normal hearing subject functional magnetic resonance imaging
functional magnetic resonance imaging
functional magnetic resonance imaging
Interventions
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functional magnetic resonance imaging
functional magnetic resonance imaging
Eligibility Criteria
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Inclusion Criteria
* SSD confirmed using evoked auditory potentials
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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University Hospital, Toulouse
OTHER
Responsible Party
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Principal Investigators
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Mathieu Marx, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital of Toulouse
Locations
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University Hospital of Toulouse
Toulouse, , France
Countries
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Other Identifiers
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13 204 02
Identifier Type: OTHER
Identifier Source: secondary_id
RC31/13/0204
Identifier Type: -
Identifier Source: org_study_id
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