Pitch Perception and Memory: Deficits and Training

NCT ID: NCT03707691

Last Updated: 2025-03-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

960 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-26

Study Completion Date

2027-10-26

Brief Summary

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Pitch perception and memory are central in auditory cognition, in particular for sound source segregation and recognition, speech prosody and music processing. Here the investigator assess pitch perception and memory in hearing-impaired listeners wearing cochlear implant(s) and listeners with congenital amusia, both compared with control listeners. Behavioral, EEG, and MEG measures are collected in audio and audio-visual contexts to characterize pitch processing deficits, and test a pitch training program.

Detailed Description

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Conditions

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Cochlear Implants

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Cochlear implant users

In both arms a pitch training protocol and a visuo-spatial training protocol are applied.

Group Type EXPERIMENTAL

Listening tests. Pitch training protocol

Intervention Type BEHAVIORAL

The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of \~20 minutes performed at home over a period of 15 weeks.

visuo-spatial training protocol

Intervention Type BEHAVIORAL

The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of \~20 minutes performed at home over a period of 15 weeks.

EEG/MEG/MRI recordings.

Intervention Type BEHAVIORAL

Listening tests. EEG/MEG/MRI recordings

Participants with Congenital Amusia

In both arms a pitch training protocol and a visuo-spatial training protocol are applied.

Group Type EXPERIMENTAL

Listening tests. Pitch training protocol

Intervention Type BEHAVIORAL

The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of \~20 minutes performed at home over a period of 15 weeks.

visuo-spatial training protocol

Intervention Type BEHAVIORAL

The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of \~20 minutes performed at home over a period of 15 weeks.

EEG/MEG/MRI recordings.

Intervention Type BEHAVIORAL

Listening tests. EEG/MEG/MRI recordings

Control Participants

Group Type EXPERIMENTAL

Listening tests. Pitch training protocol

Intervention Type BEHAVIORAL

The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of \~20 minutes performed at home over a period of 15 weeks.

visuo-spatial training protocol

Intervention Type BEHAVIORAL

The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of \~20 minutes performed at home over a period of 15 weeks.

EEG/MEG/MRI recordings.

Intervention Type BEHAVIORAL

Listening tests. EEG/MEG/MRI recordings

Interventions

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Listening tests. Pitch training protocol

The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of \~20 minutes performed at home over a period of 15 weeks.

Intervention Type BEHAVIORAL

visuo-spatial training protocol

The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of \~20 minutes performed at home over a period of 15 weeks.

Intervention Type BEHAVIORAL

EEG/MEG/MRI recordings.

Listening tests. EEG/MEG/MRI recordings

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

For adult participants:

* Aged between 18 and 90
* Absence of neurological and psychiatric disorders
* No major cognitive deficit, ability to understand and apply study instructions
* Motivation to participate efficiently in the study
* Written informed consent to participant in the study
* Affiliated to social security
* Control participants and participants with congenital amusia for Experiment 5: MRI/MEG compatibility

For underage participants:

* Subject aged 5 years and over
* Informed consent of parents or guardians for the participation of the child being studied
* No neurological or psychiatric history
* Without major cognitive impairment and ability to understand and apply setpoint.
* Subject affiliated to a social security scheme
* Motivation to participate effectively in the project

Exclusion Criteria

For adult participants:

* Age below 18 or above 90
* Pregnant or breast-feeding woman

For underage participants:

\- Pregnant or nursing minors
Minimum Eligible Age

5 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Anne CACLIN

Role: PRINCIPAL_INVESTIGATOR

Hospices Civils de Lyon

Locations

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Lyon Neuroscience Research Center

Bron, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Anne CACLIN

Role: CONTACT

4 72 13 89 04 ext. +33

Barbara Tillmann

Role: CONTACT

4 37 28 74 89 ext. +33

Facility Contacts

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Anne CACLIN, PhD

Role: primary

4 72 13 89 04 ext. +33

Barbara Tillmann, PhD

Role: backup

4 37 28 74 89 ext. +33

Other Identifiers

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2018-A02670-55

Identifier Type: OTHER

Identifier Source: secondary_id

69HCL18_0632

Identifier Type: -

Identifier Source: org_study_id

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