An Observational Study on Epithelioid Sarcoma

NCT ID: NCT03099681

Last Updated: 2025-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-08-22

Study Completion Date

2030-03-31

Brief Summary

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Prospective Italian study aimed to provide a description of the population affected by Epithelioid Sarcoma (ES)

Detailed Description

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The present prospective national study aims to provide a description of the population affected by ES, an insight into the natural history of the disease and an answer some on the outstanding questions on its management. Also, it will focus on enhancing any differences between the two ES variants (classical-type and proximal-type) in order gain a better understanding of the disease, tailor the treatment and lastly improve outcome.

Conditions

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Epithelioid Sarcoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Epitheloid Sarcoma patients

Patients with diagnosis of localized or advanced epitheloid sarcoma seen in the Italian reference centers for sarcoma treatment that receive treatment for Epitheloid Sarcoma

Treatment for Epitheloid Sarcoma

Intervention Type OTHER

Treatment Epitheloid Sarcoma according the disease guideline

Interventions

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Treatment for Epitheloid Sarcoma

Treatment Epitheloid Sarcoma according the disease guideline

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Histological diagnosis of epithelioid sarcoma according to 2014 World Health Organization (WHO) classification, performed on biopsy or surgical specimen
2. Signed informed consent
3. Adequate patient compliance to treatment or follow up
4. No age limit

Exclusion Criteria

1. Other malignancies within past 5 years, with exception of carcinoma in situ of the cervix and basocellular skin cancers treated with eradicating intent
2. Impossibility to ensure adequate compliance
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Italian Sarcoma Group

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Paolo Casali, MD

Role: PRINCIPAL_INVESTIGATOR

Fondazione IRCCS INT Milano

Locations

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Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori - IRST

Meldola, FC, Italy

Site Status RECRUITING

Istituto Europeo di Oncologia

Milan, MI, Italy

Site Status RECRUITING

Istituto Clinico Humanitas

Rozzano, MI, Italy

Site Status RECRUITING

Azienda Ospedaliera Universitaria Paolo Giaccone

Palermo, PA, Italy

Site Status RECRUITING

Fondazione del Piemonte per l'Oncologia IRCC Candiolo

Candiolo, Torino, Italy

Site Status RECRUITING

Istituto Ortopedico Rizzoli - Unit of Chemotherapy of Muscoloskeletal Tumors

Bologna, , Italy

Site Status RECRUITING

Fondazione IRCCS INT Milano

Milan, , Italy

Site Status RECRUITING

Irccs Istituto Oncologico Veneto (Iov)

Padua, , Italy

Site Status RECRUITING

Ospedale Misericordia e Dolce Ist. Toscano Tumori, Az. USL4

Prato, , Italy

Site Status RECRUITING

Campus Biomedico

Roma, , Italy

Site Status RECRUITING

Istituti Fisioterapici Ospitalieri di Roma

Roma, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Annamaria Frezza, MD

Role: CONTACT

003902390 ext. 2803

Facility Contacts

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Lorella Gurreri, MD

Role: primary

Emanuela Palmerini, MD

Role: primary

+390516366199 ext. 199

Paolo Casali, MD

Role: primary

+390223903 ext. 287

Antonella Brunello, MD

Role: primary

Bruno Vincenzi, MD

Role: primary

Virginia Ferraresi, MD

Role: primary

References

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Thway K, Jones RL, Noujaim J, Fisher C. Epithelioid Sarcoma: Diagnostic Features and Genetics. Adv Anat Pathol. 2016 Jan;23(1):41-9. doi: 10.1097/PAP.0000000000000102.

Reference Type BACKGROUND
PMID: 26645461 (View on PubMed)

Guillou L, Wadden C, Coindre JM, Krausz T, Fletcher CD. "Proximal-type" epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study of a series. Am J Surg Pathol. 1997 Feb;21(2):130-46. doi: 10.1097/00000478-199702000-00002.

Reference Type BACKGROUND
PMID: 9042279 (View on PubMed)

Chase DR, Enzinger FM. Epithelioid sarcoma. Diagnosis, prognostic indicators, and treatment. Am J Surg Pathol. 1985 Apr;9(4):241-63.

Reference Type BACKGROUND
PMID: 4014539 (View on PubMed)

Bos GD, Pritchard DJ, Reiman HM, Dobyns JH, Ilstrup DM, Landon GC. Epithelioid sarcoma. An analysis of fifty-one cases. J Bone Joint Surg Am. 1988 Jul;70(6):862-70.

Reference Type BACKGROUND
PMID: 3392084 (View on PubMed)

Halling AC, Wollan PC, Pritchard DJ, Vlasak R, Nascimento AG. Epithelioid sarcoma: a clinicopathologic review of 55 cases. Mayo Clin Proc. 1996 Jul;71(7):636-42. doi: 10.1016/S0025-6196(11)63000-0.

Reference Type BACKGROUND
PMID: 8656704 (View on PubMed)

Other Identifiers

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ISG-EPISObs

Identifier Type: -

Identifier Source: org_study_id

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