Prospective Observational Study of Localized Angiosarcoma of Any Site: ProStars

NCT ID: NCT06375941

Last Updated: 2025-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-03-29

Study Completion Date

2034-04-01

Brief Summary

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This study will be a multi-institutional, prospective, observational study of patients with localized primary AS of any site within ISG and RTR centers. Patients will be treated according to clinical practice of the center and according to ISG clinical recommendations on localized AS.

Detailed Description

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The management of localized AS remains a clinical challenge and needs to be better defined and standardized, especially with regards to the role of radiation-therapy and systemic treatment. Several questions about the best treatment approach to some clinical presentations remain open and would need to be answered by clinical studies. Unfortunately, the rarity of this histology among sarcomas makes it challenging to carry out clinical studies in all such presentations. Moreover, prognostic factors are lacking and differences in epidemiological, pathological and clinical aspects between primary AS and secondary AS need to be better characterized.

These issues may be addressed with a prospective multi-institutional observational study, through the collection of clinical and pathological data of patients with localized AS.

Involving all reference centres for sarcoma in Italy, the Italian Sarcoma Group (ISG) will be the ideal network for this study, with the collaboration of the Italian Rare Cancer Network (RTR), a 7collaborative network among Italian centres focusing on improving the quality of care of patients with rare tumors.

Conditions

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Angiosarcoma

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Pathological diagnosis of AS, any site of origin, any age, primary, localized, resectable disease.

* pathological diagnosis of AS;
* any site of origin;
* any age;
* primary, localized, resectable disease.

Observational

Intervention Type OTHER

Observational

Interventions

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Observational

Observational

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* pathological diagnosis of AS;
* any site of origin;
* any age;
* primary, localized, resectable disease.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Italian Sarcoma Group

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Elena Palassini

Role: PRINCIPAL_INVESTIGATOR

IRCCS Istituto nazionale Tumori - Milano

Locations

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Istituto Clinico Humanitas Research Hospital IRCCS

Rozzano, Milano, Italy

Site Status NOT_YET_RECRUITING

Centro Riferimento Oncologico CRO

Aviano, Pordenone, Italy

Site Status RECRUITING

AOU San Luigi Gonzaga

Orbassano, Torino, Italy

Site Status RECRUITING

Istituto Tumori "Giovanni Paolo II" I.R.C.C.S.

Bari, , Italy

Site Status NOT_YET_RECRUITING

Istituto Ortopedico Rizzoli IOR

Bologna, , Italy

Site Status RECRUITING

Policlinico "Sant'Orsola-Malpighi"

Bologna, , Italy

Site Status RECRUITING

A.O.U. Careggi

Florence, , Italy

Site Status NOT_YET_RECRUITING

Ospedale Policlinico san Martino IRCCS

Genova, , Italy

Site Status RECRUITING

IRCCS Istituto Nazionale Tumori - Milano

Milan, , Italy

Site Status RECRUITING

IRCCS Istituto Europeo di Oncologia

Milan, , Italy

Site Status NOT_YET_RECRUITING

Fondazione Irccs San Gerardo Dei Tintori

Monza, , Italy

Site Status NOT_YET_RECRUITING

Istituto Nazionale Tumori_Fondazione "G.Pascale"

Napoli, , Italy

Site Status RECRUITING

IOV Istituto Oncologico Veneto IRCCS

Padua, , Italy

Site Status RECRUITING

Policlinico "Paolo Giaccone"

Palermo, , Italy

Site Status RECRUITING

Nuovo Ospedale di Prato - S. Stefano

Prato, , Italy

Site Status RECRUITING

Fondazione Policlinico Campus Biomedico

Roma, , Italy

Site Status RECRUITING

IRCCS Istituti Fisioterapici Ospitalieri

Roma, , Italy

Site Status NOT_YET_RECRUITING

ASL Ospedale San Giovanni Bosco

Torino, , Italy

Site Status RECRUITING

Ospedale di Trento

Trento, , Italy

Site Status NOT_YET_RECRUITING

Countries

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Italy

Central Contacts

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Gianluca Ignazzi

Role: CONTACT

+393335359192

Viviana Appolloni

Role: CONTACT

Facility Contacts

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Alexia Bertuzzi, MD

Role: primary

Federico Navarria, MD

Role: primary

Lorenzo D'Ambrosio, MD

Role: primary

Sabino Strippoli, MD

Role: primary

Toni Ibrahim, MD

Role: primary

Maria Abbondanza Pantaleo, Prof.

Role: primary

Lorenzo Livi, MD

Role: primary

Danila Comandini, MD

Role: primary

Palassini Elena

Role: primary

Elisabetta Pennacchioli, MD

Role: primary

Marinella Mastore, MD

Role: primary

Lucia Cannella, MD

Role: primary

Antonella Brunello

Role: primary

Giuseppe Badalamenti, Prof.

Role: primary

Giacomo Giulio Baldi

Role: primary

Bruno Vincenzi, prof

Role: primary

Virginia Ferraresi, MD

Role: primary

Antonella Boglione, MD

Role: primary

Marco Cianchetti, MD

Role: primary

Related Links

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https://www.italiansarcomagroup.org/

Italian Sarcoma Group website

Other Identifiers

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ProStars

Identifier Type: -

Identifier Source: org_study_id

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