Transfer Strategy in an Oocyte Donation Programme

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

134 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-05

Study Completion Date

2019-08-31

Brief Summary

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It has been previously shown that although the activation of the embryonic genome can begin as early as two days of initiation of the embryonic development (D2), it is expressed on day 3 (D3). Without this activation, the embryo can not continue its development. Therefore, it has been suggested that extended culture to blastocyst stage could be an option to identify and better select embryos that have been able to carry out this activation. The purpose of this study is to compare cumulative pregnancy and live birth rates following transfer of cleavage embryos or blastocysts.

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Detailed Description

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Conditions

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Oocyte Donation Infertility, Female Embryo Transfer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Blastocyst-stage embryo transfer strategy

Group Type EXPERIMENTAL

Blastocyst-stage embryo transfer strategy

Intervention Type PROCEDURE

Intra-uterine transfer of blastocist if in cleavage embryo stage the oocyte recipient has a mínimum of 3 availables embryos with at least one of good quality to transfer and also the inta-uterine transfer of cleavage embryo (day 3) when the recipient doesn't have the previous criteria.

Cleavage-stage embryo transfer strategy

Group Type ACTIVE_COMPARATOR

Cleavage-stage embryo transfer strategy

Intervention Type PROCEDURE

Inta-uterine transferring of cleavage embryo transfer (day 3 of develpment) in oocyte recipients

Interventions

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Blastocyst-stage embryo transfer strategy

Intra-uterine transfer of blastocist if in cleavage embryo stage the oocyte recipient has a mínimum of 3 availables embryos with at least one of good quality to transfer and also the inta-uterine transfer of cleavage embryo (day 3) when the recipient doesn't have the previous criteria.

Intervention Type PROCEDURE

Cleavage-stage embryo transfer strategy

Inta-uterine transferring of cleavage embryo transfer (day 3 of develpment) in oocyte recipients

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients under their first or second cycle of a synchronous (fresh) oocyte donation cycle.

Exclusion Criteria

* Preimplantation genetic screening or diagnosis cycles.
* Patients with strict blastocyst-stage embryo transfer indication by the couple's treating physician.

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No