Natural Cycle Versus Endometrial Preparation for Healthy Blastocyst Transfer

NCT ID: NCT02378584

Last Updated: 2016-01-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

236 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-02-28

Study Completion Date

2015-09-30

Brief Summary

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This study evaluates the difference in pregnancy rate transferring a healthy blastocyst in natural or artificial cycle.

Detailed Description

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The aim of the study was to verify the implantation capacity and ongoing pregnancy rate of vitrified warmed euploid blastocyst in natural cycle versus endometrial artificial cycle with gonadotropin-releasing hormone (GnRH-agonist) pituitary suppression.

Conditions

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Infertility

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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natural cycle

Ultrasound controls and endocrine blood test to asses the day of ovulation for embryo transfer

Group Type OTHER

embryo transfer

Intervention Type OTHER

healthy blastocyst transfer in natural and hormonal cycle

hormonal cycle

Ultrasound controls and endocrine blood test to asses the endometrium thickness for embryo transfer

Group Type ACTIVE_COMPARATOR

embryo transfer

Intervention Type OTHER

healthy blastocyst transfer in natural and hormonal cycle

Interventions

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embryo transfer

healthy blastocyst transfer in natural and hormonal cycle

Intervention Type OTHER

Other Intervention Names

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drug adminstration, clinical controls

Eligibility Criteria

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Inclusion Criteria

* frozen-thawed healthy blastocyst

Exclusion Criteria

* post thawed not survival healthy blastocyst
Minimum Eligible Age

20 Years

Maximum Eligible Age

42 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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European Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ERmanno Greco, MD

Role: STUDY_DIRECTOR

European Hospital

Locations

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European Hospital

Rome, RM, Italy

Site Status

European Hospital

Rome, Roma, Italy

Site Status

Countries

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Italy

References

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Greco E, Litwicka K, Arrivi C, Varricchio MT, Caragia A, Greco A, Minasi MG, Fiorentino F. The endometrial preparation for frozen-thawed euploid blastocyst transfer: a prospective randomized trial comparing clinical results from natural modified cycle and exogenous hormone stimulation with GnRH agonist. J Assist Reprod Genet. 2016 Jul;33(7):873-84. doi: 10.1007/s10815-016-0736-y. Epub 2016 May 24.

Reference Type DERIVED
PMID: 27221477 (View on PubMed)

Other Identifiers

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CC1978MA

Identifier Type: -

Identifier Source: org_study_id

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