Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
400 participants
INTERVENTIONAL
2015-02-28
2016-02-29
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Young age group-Luteal phase
Endometrial injury in luteal phase (previous menstrual cycle) for patients undergoing Frozen thawed embryo transfer.
endometrial scratch
local injury to the endometrium by Pipelle
Young age group-Early follicular phase
Endometrial injury in early follicular phase for patients undergoing Frozen thawed embryo transfer.
endometrial scratch
local injury to the endometrium by Pipelle
Advanced age group-Luteal phase
Endometrial injury in luteal phase (previous menstrual cycle) for patients undergoing Frozen thawed embryo transfer.
endometrial scratch
local injury to the endometrium by Pipelle
Advanced age group-Early follicular phase
Endometrial injury in early follicular phase for patients undergoing Frozen thawed embryo transfer.
endometrial scratch
local injury to the endometrium by Pipelle
Interventions
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endometrial scratch
local injury to the endometrium by Pipelle
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* At least one period IVF-ET (fresh or thaw) has been done and not pregnant after at least one qualified blastocyst (more than 3BB) or two qualified embryos (more than II/6) have been transferred;
* There are qualified embryos thawed and the thaw-ET period will be taken.
Exclusion Criteria
* History of endometrial diseases: such as intrauterine adhesion, uterine cavity tuberculosis, severe dysplasia of endometrium, etc.;
* Multiple myomata or endometrioma which causes uterus oppression;
* Multiple and recurrent endometrial polyps;
* Pelvic tuberculosis, endometriosis.
20 Years
40 Years
FEMALE
Yes
Sponsors
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The First Affiliated Hospital of Zhengzhou University
OTHER
Responsible Party
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Yingpu Sun
Director of Reproductive Medical Center
Principal Investigators
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Yingpu Sun, MD,PhD
Role: STUDY_CHAIR
Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University
Locations
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Reproductive Medical Center, 1st Affiliated hospital of Zhengzhou University
Zhengzhou, Henan, China
Countries
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Central Contacts
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Facility Contacts
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Yang Wang, M.D
Role: primary
References
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Yeung TW, Chai J, Li RH, Lee VC, Ho PC, Ng EH. The effect of endometrial injury on ongoing pregnancy rate in unselected subfertile women undergoing in vitro fertilization: a randomized controlled trial. Hum Reprod. 2014 Nov;29(11):2474-81. doi: 10.1093/humrep/deu213. Epub 2014 Sep 8.
Nastri CO, Lensen SF, Gibreel A, Raine-Fenning N, Ferriani RA, Bhattacharya S, Martins WP. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev. 2015 Mar 22;(3):CD009517. doi: 10.1002/14651858.CD009517.pub3.
Potdar N, Gelbaya T, Nardo LG. Endometrial injury to overcome recurrent embryo implantation failure: a systematic review and meta-analysis. Reprod Biomed Online. 2012 Dec;25(6):561-71. doi: 10.1016/j.rbmo.2012.08.005. Epub 2012 Sep 12.
El-Toukhy T, Sunkara S, Khalaf Y. Local endometrial injury and IVF outcome: a systematic review and meta-analysis. Reprod Biomed Online. 2012 Oct;25(4):345-54. doi: 10.1016/j.rbmo.2012.06.012. Epub 2012 Jun 26.
Dain L, Ojha K, Bider D, Levron J, Zinchenko V, Walster S, Dirnfeld M. Effect of local endometrial injury on pregnancy outcomes in ovum donation cycles. Fertil Steril. 2014 Oct;102(4):1048-54. doi: 10.1016/j.fertnstert.2014.06.044. Epub 2014 Jul 23.
Other Identifiers
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RMCZZU-EEI
Identifier Type: -
Identifier Source: org_study_id
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