Success Rate Natural Cycles Versus Modified Natural Cycles in Frozen Embryos

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2019-12-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Immediate Versus Delayed Natural Cycle Frozen Embryo Transfers

NCT05215119

Clinical Pregnancy

COMPLETED

Does the Embryo Transfer Technique Affect the Success of in Vitro Fertilization?

NCT03756857

Infertility Assisted Reproductive Technology IVF

UNKNOWN NA

The Effect of Embryo Transfer Technique on Pregnancy Outcomes in HRT-FET Cycles

NCT05564312

Infertility

UNKNOWN

Natural Cycles With Spontaneous Versus Induced Ovulation in FET

NCT03581422

Embryo Transfer

COMPLETED

Natural Cycle Versus Stimulated Cycle Before Frozen Embryo Transfer

NCT02834117

Fertility

COMPLETED PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer, with reports from observational studies and randomized controlled trials suggesting that:

1. The endometrium in stimulated cycles is not optimal for implantation
2. Pregnancy rates are increased following FET
3. Perinatal outcomes are less affected after FET
4. Preimplantation genetic screening We will follow only natural and modified natural cycles patients. Spontaneous ovulation will documented with hormonal and sonographic monitoring. Hormonal monitoring are including estradiol and luteinizing hormone (LH). Sonographic monitoring is including follicule diameter (16-20 mm). At modified natural cycles we will use hCG triggering for ovulation approximately 16-20 mm diameter.

We will compare success rate between natural and modified natural cycles

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Infertility, Female

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Natural frozen embryo transfer group

In this group all embryos will be frozen when transfer planned sonographic follicle diameter measured. After spontaneous ovulation, embryo transfer will be planned. Luteal phase support will not be used.

natural cycle

Intervention Type OTHER

When follicle is ready for ovulation, we will use this injection by intra-dermal route

modified natural cycle

Intervention Type OTHER

we will use that drug in the natural modified transfer group after embryo transfer

embryo transfer

Intervention Type OTHER

we will do transfer when the endometrium is ready

modified natural embryo transfer group

In this group all embryos will be frozen when transfer planned sonographic follicle diameter measured. When follicle diameter is 16-17 mm we will apply hCG (recombinant hCG). After ovulation, embryo transfer will be done. Luteal phase support will not be used.

natural cycle

Intervention Type OTHER

When follicle is ready for ovulation, we will use this injection by intra-dermal route

modified natural cycle

Intervention Type OTHER

we will use that drug in the natural modified transfer group after embryo transfer

embryo transfer

Intervention Type OTHER

we will do transfer when the endometrium is ready

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

natural cycle

When follicle is ready for ovulation, we will use this injection by intra-dermal route

Intervention Type OTHER

modified natural cycle

we will use that drug in the natural modified transfer group after embryo transfer

Intervention Type OTHER

embryo transfer

we will do transfer when the endometrium is ready

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

natural LH surge recombinant hcg frozen embryo transfer

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patient who are admitted to the IVF center and who will be transferred to frozen embryos.
* Infertile women under 40 years of age who accepted this study.
* Unexplained infertilite couple.
* All ovulatory patient.
* Male factor.
* Tubal factor.