Serum Vitamin D Levels and Pregnancy Rates in Women Undergoing Elective Frozen Embryo Transfer (eFET)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-04-30

Study Completion Date

2016-07-31

Brief Summary

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The aim of this study is determining the affects of serum vitamin D levels to implantation and clinical pregnancy rates in women undergoing elective vitrified/thawed embryo transfer. Two groups will be identified according to the serum vitamin D levels on eFET transfer day and later on implantation, clinical pregnancy and ongoing pregnancy rates will be compared between those groups

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Detailed Description

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In the last decade there have been growing evidence about Vitamin D receptors and their role in female genital tract. But these studies are yet not well designed and the results should be interpreted cautiously. Although some of these studies advocating the Vitamin D deficiency as an negative circumstance on pregnancy rates some of the others don't agree. According to contradictory results understanding the actual role of those receptors needs more observation.

Latest retrospective analyse postulated that, vitamin D deficiency in fresh single embryo transfer cycles may reduce pregnancy rates mediated by endometrium or ovarian reserve and stimulation characteristics.

For this reason the investigators aimed to explore the effect of serum Vitamin D levels on pregnancy rates in infertile population undergoing frozen embryo transfer.

Conditions

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Pregnancy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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vitamin D deficient patients

Serum 25- (hydroxide) OH Vitamin D levels \<20ng/L undergoing Frozen embryo transfer (Vitamin D levels are measured on the day of embryo transfer)

frozen embryo transfer

Intervention Type PROCEDURE

comparison of groups according to their serum vitamin D levels on frozen embryo transfer day

vitamin D sufficient patients

Serum 25- (hydroxide) OH Vitamin D levels \>20ng/L undergoing Frozen embryo transfer (Vitamin D levels are measured on the day of embryo transfer)

frozen embryo transfer

Intervention Type PROCEDURE

comparison of groups according to their serum vitamin D levels on frozen embryo transfer day

Interventions

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frozen embryo transfer

comparison of groups according to their serum vitamin D levels on frozen embryo transfer day

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 18 years to 35 years age, a frozen ET with 1 Day 5 (blastocyst stage) embryo
* Infertile women undergoing ICSI (intracytoplasmic sperm injection) cycle
* Factors affecting fertility are Tubal
* Unexplained or ovulatory disturbances,