Evaluation of the Risk Associated With Impulsivity and Other Neuropsychological Factors on Suicidal Relapse Within Hospital Emergencies

NCT ID: NCT03026387

Last Updated: 2022-09-28

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 650 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-05-05
• Study Completion Date: 2024-10-31

Brief Summary

Suicidal behavior (SB) is a major public health problem in France, with over 10,000 suicides (6th in the EU28) and 220,000 suicide attempts (SA) per year. These data seem underestimated by 20%. A large percentage of men (6%) and women (9%) in France made at least one lifetime SA. In addition, SBs are common among young people and are the second leading cause of death among 15-44 year-olds. The interaction of multiple factors in SB complicates the creation of predictive models. These are currently imprecise and prevent the development of consensual recommendations for the management of suicidal patients.

Most suicide attempters are evaluated in the emergency room where it is imperative to identify people with a high risk of relapse. Risk assessment is generally based on the experience of the practitioner who uses psychometric scales as support for clinical decisions. This assessment could be improved and supplemented by other sources of information. Thus, we aim to develop a short and specific tool that combines:

1. Neurocognitive measures carried out using computer software on domains strongly associated with SB: impulsivity, affective dysregulation, alterations in decision-making (risky choices), selective attention and verbal fluency.

2. Clinical and psychological assessment including the most predictive items of future SA: life events (environment) and personality traits (vulnerability). Suicide attempters will be assessed for SB and suicidal ideation in the emergency department. These measures will be repeated during a 12-month follow-up. We will use the data obtained to provide a more accurate measure of risk.

Detailed Description

Over 65 months, 5 emergency departments (Montpellier, Nimes, Uzès, Nice, Marseille) will recruit a total of 650 patients who attempted suicide.

• First visit: clinical and neuropsychological assessment
• Second and third visits at 6 and 12 months: assessment of SBs and suicidal relapse, clinical and neuropsychological assessment.

Conditions

Suicide Attempt

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Neuropsychological battery tests

All participants performed the same evaluation: clinical and neuropsychological assessment.

All of them are suicide attempters without psychotic features

Group Type: OTHER

Neuropsychological battery tests

Intervention Type: BEHAVIORAL

The neuropsychological battery tests is composed with: Continuous Performance Test, Iowa Gambling Test, Verbal fluency (animals), Emotional stroop, Self-injury implicit association test and N-back test.

The neuropsychological battery assesses domains heavily involved in suicidal behavior: impulsivity, affective dysregulation, alterations in decision-making (risky choices), selective attention,verbal fluidity and working memory.

Interventions

Neuropsychological battery tests

The neuropsychological battery tests is composed with: Continuous Performance Test, Iowa Gambling Test, Verbal fluency (animals), Emotional stroop, Self-injury implicit association test and N-back test.

The neuropsychological battery assesses domains heavily involved in suicidal behavior: impulsivity, affective dysregulation, alterations in decision-making (risky choices), selective attention,verbal fluidity and working memory.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Being at least 18 years old
• Have committed a suicide attempt within 7 days prior to inclusion
• Receive minimal treatment (assessed by the clinician)
• Sign the informed consent
• Be able to understand the nature, the aims and the methodology of the study

Exclusion Criteria

• Patient with an actual or past history of psychotic disorder
• Patient not affiliated to a French social security system.
• Patient deprived of liberty (judicial or administrative decision)
• Patient aged 65 years or older with an MMSE score <24 at baseline.
• Patient in exclusion period after participation in another project
• Patient who has already achieved 4500€ of annual research allowances

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Institute of Health and Medical Research 1061, Montpellier

UNKNOWN

Sponsor Role: collaborator

University Hospital, Montpellier

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jorge LOPEZ-CASTROMAN, MD

Role: PRINCIPAL_INVESTIGATOR

Centre Hospitalier Universitaire de Nīmes

Locations

Montpellier University Hospital

Montpellier, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Jorge LOPEZ-CASTROMAN, MD

Role: CONTACT

jorge.lopezcastroman@chu-nimes.fr

+33 4 66 68 34 26

Facility Contacts

Catherine GENTY, MD

Role: primary

c-genty@chu-montpellier.fr

+33 4 67 99 61 45 75

Other Identifiers

2016-A00845-46

Identifier Type: OTHER

Identifier Source: secondary_id

UF 9681

Identifier Type: -

Identifier Source: org_study_id