Pain Perception in Suicidal Behavior Vulnerability

NCT ID: NCT02915679

Last Updated: 2022-01-11

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 167 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-06-17
• Study Completion Date: 2021-05-06

Brief Summary

In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality. According to interpersonal psychological theory of suicide, the repeated exposition to stressful and painful events (as physical abuse) would facilitate suicide attempt through the increased pain tolerance. The social pain (or psychical pain on the broader sense) and physical pain are closely linked.

The investigators hypothesize that the measure of painful perception will be significantly superior on suicidals attempters compared to non-attempters. It will be the case for recent suicide attempters and former suicide attempters, suggesting a suicidal vulnerability trait. Moreover, the investigators expect that social distress induced by a social exclusion paradigm will be significantly superior on suicide attempters compared to non-attempters.

The aim of the study is to investigate the physical and psychic pain on depressed subjects with or without history of suicide attempts.

After a clinical evaluation (psychiatric symptomatology, personality trait, suicidal dimension), subjects will be submitted to a painful thermic stimulation and will participate at a computer test of social exclusion (named Cyberball).

Detailed Description

242 depressed patients ( 81 recent suicide attempters, 81 former suicide attempters, 80 non-attempters)

First visit : clinical assessment Second visit : pain evaluation and blood sample (from one day to a week maximum after the first visit).

Conditions

Major Depressive Episode

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Study participant

All the participants performed blood sample for genetic purpose, psychiatric assessment and pain investigation:

• 81 depressed patients admitted after a recent suicidal act (<8 days)
• 81 depressed subjects with a past history of suicidal act (>1month)
• 80 depressed subjects without any personal history of suicidal behaviour

Group Type: OTHER

Blood sample for genetic purpose, psychiatric assessment and pain investigation

Intervention Type: OTHER

All the participant will performed the same evaluation and blood analysis:

• A clinical assessment by psychiatrics assessing psychiatric disorder and suicidal behavior
• Thermal stimulation for pain assessment
• Computer game named Cyberball: test of social exclusion
• Self report questionnaire for the assessment of reject sensitivity, relationship style, impulsivity, childhood trauma.
• Routine blood sampling

Interventions

Blood sample for genetic purpose, psychiatric assessment and pain investigation

All the participant will performed the same evaluation and blood analysis:

• A clinical assessment by psychiatrics assessing psychiatric disorder and suicidal behavior
• Thermal stimulation for pain assessment
• Computer game named Cyberball: test of social exclusion
• Self report questionnaire for the assessment of reject sensitivity, relationship style, impulsivity, childhood trauma.
• Routine blood sampling

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• aged by 18 years old
• came from West Europe, excepted Basque and Sardinian (because of genetics analysis)
• main diagnosis of major depressive episode (DSM V criteria)
• not having take antalgics in the 24 hours before assessment
• received a minimal psychotrope treatment (clinician evaluation)
• Able to understand nature, aims, methodology of the study
• Agree to cooperate in clinical and biological assessment
• Having signed informed consent

81 recent suicide attempters (being hospitalised for suicidal attempts and having realised a suicide attempts 8 days before inclusion) 81 former suicide attempters (having realised in his lifetime a suicide attempt, one month before inclusion)

Exclusion Criteria

• Current diagnosis of manic, hypomanic or alcohol dependance or substance abuse in the last 6 months, or diagnosis of schizophrenia or schizoaffective disorder in his lifetime
• Current algic and chronic neurologic disease
• Current or actual treatment by tricyclic antidepressant and Serotonin and norepinephrine reuptake inhibitors(SNRIs)
• Pregnancy
• Patients on protective measure

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital, Montpellier

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Montpellier Hospital University

Montpellier, , France

Countries

France

Other Identifiers

2013-A01029-36

Identifier Type: OTHER

Identifier Source: secondary_id

UF 9185

Identifier Type: -

Identifier Source: org_study_id