FLT-PET for Early Detection of Relapse in Patients With Irradiated Lung Cancer

NCT ID: NCT02995889

Last Updated: 2022-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-11-30

Study Completion Date

2020-02-07

Brief Summary

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This study investigates the feasibility of FLT-PET to improve the diagnosis of relapse in patients with irradiated lung cancer in comparison with FDG-PET/CT.

Detailed Description

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Conditions

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Lung Cancer, Nonsmall Cell Small Cell Lung Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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FLT-PET

Group Type EXPERIMENTAL

FLT-PET

Intervention Type DEVICE

Interventions

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FLT-PET

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* history with lung cancer, small cell or non-small cell
* radiotherapy of lung cancer ended within the last 24 months
* radiotherapy might be normofractionated or stereotactic
* current suspicion of relapse
* written and oral consent

Exclusion Criteria

* communication difficulties
* pregnancy or lactation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Responsible Party

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Tine Nøhr Christensen

MD, research fellow

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andreas Kjær, MD phD MDSci

Role: STUDY_CHAIR

Dept of Clinical Physiology, Nuclear medicine and PET, Rigshospitalet, Denmark

Locations

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Dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet

Copenhagen, , Denmark

Site Status

Dept. Respiratory Medicine, Bispebjerg University Hospital

Copenhagen, , Denmark

Site Status

Countries

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Denmark

References

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Christensen TN, Langer SW, Persson G, Larsen KR, Loft A, Amtoft AG, Berthelsen AK, Johannesen HH, Keller SH, Kjaer A, Fischer BM. 18F-FLT PET/CT Adds Value to 18F-FDG PET/CT for Diagnosing Relapse After Definitive Radiotherapy in Patients with Lung Cancer: Results of a Prospective Clinical Trial. J Nucl Med. 2021 May 10;62(5):628-635. doi: 10.2967/jnumed.120.247742. Epub 2020 Oct 9.

Reference Type RESULT
PMID: 33037090 (View on PubMed)

Christensen TN, Langer SW, Persson G, Larsen KR, Amtoft AG, Keller SH, Kjaer A, Fischer BM. Impact of [18F]FDG-PET and [18F]FLT-PET-Parameters in Patients with Suspected Relapse of Irradiated Lung Cancer. Diagnostics (Basel). 2021 Feb 11;11(2):279. doi: 10.3390/diagnostics11020279.

Reference Type RESULT
PMID: 33670242 (View on PubMed)

Other Identifiers

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308_14

Identifier Type: -

Identifier Source: org_study_id

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