FLT-PET/DW-MRI for Detection of Brain Metastases and Early Therapy Evaluation in Patients With Small Cell Lung Cancer

NCT ID: NCT02995902

Last Updated: 2022-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-12-11

Study Completion Date

2018-02-08

Brief Summary

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The purpose of the study is to determine the value of FLT-PET early after initiated chemotherapy in patients with small cell lung cancer, and to determine whether MRI of the brain should be performed routinely in these patients.

Detailed Description

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Conditions

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Small Cell Lung Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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FLT-PET/MRI

Group Type EXPERIMENTAL

FLT-PET

Intervention Type DEVICE

MRI

Intervention Type DEVICE

Interventions

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FLT-PET

Intervention Type DEVICE

MRI

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* biopsy proven small cell lung cancer
* referred for standard chemotherapy
* oral and written informed consent

Exclusion Criteria

* metal or electronical devices in the body not compatible with MRI of brain or thorax
* pregnancy or lactation
* communication difficulties
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Responsible Party

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Tine Nøhr Christensen

MD, research fellow

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andreas Kjær, MD phD MDSci

Role: STUDY_CHAIR

Dept of Clinical Physiology, Nuclear medicine and PET, Rigshospitalet, Denmark

Locations

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Dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet

Copenhagen, , Denmark

Site Status

Countries

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Denmark

References

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Christensen TN, Langer SW, Villumsen KE, Johannesen HH, Lofgren J, Keller SH, Hansen AE, Kjaer A, Fischer BM. 18F-fluorothymidine (FLT)-PET and diffusion-weighted MRI for early response evaluation in patients with small cell lung cancer: a pilot study. Eur J Hybrid Imaging. 2020 Jan 27;4(1):2. doi: 10.1186/s41824-019-0071-5.

Reference Type RESULT
PMID: 34191195 (View on PubMed)

Other Identifiers

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307_14

Identifier Type: -

Identifier Source: org_study_id

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