PET and MRI Imaging of Brain Tumors Using [18F]PARPi

NCT ID: NCT04173104

Last Updated: 2025-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

EARLY_PHASE1

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-01

Study Completion Date

2026-11-30

Brief Summary

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This study is to collect data about how 18FPARPi can be used together with PET/positron emission tomography and MRI/magnetic resonance imaging scans to take pictures of brain cancer

Detailed Description

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Conditions

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Brain Tumor Brain Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Participants with Brain Cancer

Participants with new or suspected recurrent brain tumors

Group Type EXPERIMENTAL

PET/MR with [18F]PARPi

Intervention Type DIAGNOSTIC_TEST

One PET/MR study (with up to 3 scan times) with \[18F\]PARPi

[18F]PARPi

Intervention Type DRUG

Injection of \<100ug of \[18F\]PARPi prior to 1 PET/MR

Interventions

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PET/MR with [18F]PARPi

One PET/MR study (with up to 3 scan times) with \[18F\]PARPi

Intervention Type DIAGNOSTIC_TEST

[18F]PARPi

Injection of \<100ug of \[18F\]PARPi prior to 1 PET/MR

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with new or suspected recurrent brain tumors (including suspected recurrent brain tumors showing growth from any preceding scan)
* Age \>/= 18 years
* Minimum at least one brain lesion size \>/= 1.5cm diameter
* Scheduled to undergo treatment at MSK
* Willingness to sign informed consent
* Able to receive intravenous gadolinium contrast per MSK Department of Radiology guidelines

Exclusion Criteria

* Any contraindication to 3T MRI (PET/MR scanner is 4.0 Tesla)
* Pregnancy or breast-feeding women
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Memorial Sloan Kettering Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Robert Young, MD

Role: PRINCIPAL_INVESTIGATOR

Memorial Sloan Kettering Cancer Center

Locations

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Memorial Sloan Kettering Cancer Center

New York, New York, United States

Site Status

Countries

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United States

Related Links

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http://www.mskcc.org

Memorial Sloan Kettering Cancer Center

Other Identifiers

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19-311

Identifier Type: -

Identifier Source: org_study_id

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