Pilot Study of 18F-FLT PET

NCT ID: NCT00585741

Last Updated: 2012-02-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-12-31

Study Completion Date

2011-12-31

Brief Summary

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Fractionated radiotherapy induces an observable change in the proliferative activity as assessed by pre-treatment and early-treatment 18F-FLT PET imaging. This study is designed to investigate 18F-FLT as a PET imaging agent for predicting treatment effectiveness in several tumors and will serve as a pilot study to a planned PO1 submission

Detailed Description

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Conditions

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CNS Brain Metastasis Head and Neck Cancer Lung Cancer Prostate Cancer Esophageal Cancer

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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2. Head and neck

Imaging with 18F-FLT PET

Group Type EXPERIMENTAL

Imaging with 18F-FLT PET

Intervention Type PROCEDURE

Imaging with 18F-FLT PET

3. Lung

Imaging with 18F-FLT PET

Group Type EXPERIMENTAL

Imaging with 18F-FLT PET

Intervention Type PROCEDURE

Imaging with 18F-FLT PET

4. prostate

Imaging with 18F-FLT PET

Group Type EXPERIMENTAL

Imaging with 18F-FLT PET

Intervention Type PROCEDURE

Imaging with 18F-FLT PET

5. esophagus

Imaging with 18F-FLT PET

Group Type EXPERIMENTAL

Imaging with 18F-FLT PET

Intervention Type PROCEDURE

Imaging with 18F-FLT PET

1.CNS

Imaging with 18F-FLT PET

Group Type EXPERIMENTAL

Imaging with 18F-FLT PET

Intervention Type PROCEDURE

Imaging with 18F-FLT PET

Interventions

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Imaging with 18F-FLT PET

Imaging with 18F-FLT PET

Intervention Type PROCEDURE

Imaging with 18F-FLT PET

Imaging with 18F-FLT PET

Intervention Type PROCEDURE

Imaging with 18F-FLT PET

Imaging with 18F-FLT PET

Intervention Type PROCEDURE

Imaging with 18F-FLT PET

Imaging with 18F-FLT PET

Intervention Type PROCEDURE

Imaging with 18F-FLT PET

Imaging with 18F-FLT PET

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Able to tolerate a PET/CT scan
* Age of 18 or older
* signed informed consent
* being considered for radiotherapy for treatment of CNS mets, Head and neck cancer, lung cancer, prostate cancer or esophageal cancer

Exclusion Criteria

* Prior XRT to site being studied
* severe claustrophobia or inability to tolerate PET/CT
* unable to provide written consent
* pregnant or breastfeeding women
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University of Wisconsin, Madison

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Robert Jeraj, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Wisconsin, Madison

Locations

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University of Wisconsin Hospital and clinis

Madison, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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HSC-2006-0280

Identifier Type: -

Identifier Source: org_study_id

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