Emotional Lived in Patients Suffering From Psychogenic Nonepileptic Seizures : Study by Functional Magnetic Resonance Imaging
NCT ID: NCT02976545
Last Updated: 2024-03-15
Study Results
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Basic Information
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COMPLETED
NA
68 participants
INTERVENTIONAL
2017-10-03
2022-09-30
Brief Summary
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The hypothesis of a disorder of emotional experience is mainly based on behavioral data and disturbance of autonomic responses in response to images in emotional content (Mignot et al 2015, in submission; Bakvis et al 2013). Various imaging studies have identified brain structures belonging to the limbic system in particular that seem functionally impaired in this population. These functional connectivity abnormalities are correlated with dissociation scores in PNES patients (Van der Kruijs et al 2012 and 2014).
Investigators propose to specifically study the brain activity of PNES patients during tasks emotional content to identify the mechanisms involved in this emotional dysregulation. This work is essential to understanding the mechanisms and the development of new therapeutic strategies
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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PNES
Psychogenic Non-epileptic Seizures subjects
fMRI (functional Magnetic Resonance Imaging)
fMRI examination
psychiatric evaluation
psychiatric evaluation
PTSD
Post Traumatic Stress Disorder
fMRI (functional Magnetic Resonance Imaging)
fMRI examination
psychiatric evaluation
psychiatric evaluation
Healthy controls
Healthy controls
fMRI (functional Magnetic Resonance Imaging)
fMRI examination
psychiatric evaluation
psychiatric evaluation
Interventions
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fMRI (functional Magnetic Resonance Imaging)
fMRI examination
psychiatric evaluation
psychiatric evaluation
Eligibility Criteria
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Inclusion Criteria
* Right-handed
* Affiliation to the French social security system,
* Informed signing of the study consent.
* PNES diagnosed by a neurologist specialized in epilepsy, based on clinical symptoms analysis and video-EEG recording,
* Absence of concomitant epilepsy.
Exclusion Criteria
* Neurological history or comorbidity (epilepsy included),
* Current neurological treatment,
* Posology change or introduction of psychoactive treatment dating back to less than a month,
* Psychotic comorbidity (schizophrenia),
* Addiction history apart for smoking,
* History of head trauma,
* Mental retardation,
* Being the subject of articles L.1121-5 to L.1121-8 and L1122-1-2 of the French Code of Public Health (i.e. being a not responsible adult),
* Lack of French language proficiency or inability to understand instructions,
* Uncorrected visual impairment,
* Any contraindication to MRI (pacemaker, ferromagnetic foreign body, claustrophobia, etc.).
* Diagnosis of PTSD challenged or denied by the patient, current or history of functional neurological symptom disorder,
* History of PNES (conversion disorder).
* History of PTSD,
* History of PNES (conversion disorder).
18 Years
FEMALE
Yes
Sponsors
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Central Hospital, Nancy, France
OTHER
Responsible Party
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M.D. Coraline HINGRAY
Doctor
Locations
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CHRU de Nancy
Nancy, , France
Countries
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References
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Fauve P, Tyvaert L, Husson C, Hologne E, Gao X, Maillard L, Schwan R, Banasiak C, El-Hage W, Hossu G, Hingray C. Functional MRI-based study of emotional experience in patients with psychogenic non-epileptic seizures: Protocol for an observational case-control study-EMOCRISES study. PLoS One. 2022 Jan 7;17(1):e0262216. doi: 10.1371/journal.pone.0262216. eCollection 2022.
Other Identifiers
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2016-A01295-46
Identifier Type: -
Identifier Source: org_study_id
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