Blood Flow Analysis of the Human Mucosa After Vestibuloplasty Procedures
NCT ID: NCT02975024
Last Updated: 2018-04-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
8 participants
OBSERVATIONAL
2016-11-30
2017-12-31
Brief Summary
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Detailed Description
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LSCI is a non-invasive, two dimensional method to evaluate microcirculation of different tissues. This new method let us monitor the entire surgical area real-time during the healing period.
The aim of the present study is to define blood flow patterns, which might characterize the wound healing of such surgical procedures during the first 6 months of healing in order to facilitate treatment.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Mucograft
Laser speckle contrast imaging of the oral mucosa and wound fluid measurement and quantitative determination of VEGF after mandibular vestibuloplasty. Individuals of this pre-defined group are candidates of vestibuloplasty, where the keratinized gingiva will be enlarged by a combination of apically repositioned split thickness flap with a xenogeneic collagen matrix (Mucograft).
laser speckle contrast imaging of the oral mucosa
Non-invasive method to measure tissue blood perfusion applied for oral mucosa
wound fluid measurement
Wound fluid at the wound margin is collected using filter strip and volumetrically measured by Periotron 8010 instrument.
quantitative determination of VEGF
For the quantitative determination of VEGF in the fourth day wound fluid sample the Human VEGF Quantikine ELISA Kit will be used.
strip gingival graft + Mucograft
Laser speckle contrast imaging of the oral mucosa and wound fluid measurement and quantitative determination of VEGF after mandibular vestibuloplasty. Individuals of this pre-defined group are candidates of vestibuloplasty, where the keratinized gingiva will be enlarged by a combination of apically repositioned split thickness flap with a strip gingival graft and a xenogeneic collagen matrix (Mucograft). The strip gingival graft is harvested from the patient's palate.
laser speckle contrast imaging of the oral mucosa
Non-invasive method to measure tissue blood perfusion applied for oral mucosa
wound fluid measurement
Wound fluid at the wound margin is collected using filter strip and volumetrically measured by Periotron 8010 instrument.
quantitative determination of VEGF
For the quantitative determination of VEGF in the fourth day wound fluid sample the Human VEGF Quantikine ELISA Kit will be used.
Interventions
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laser speckle contrast imaging of the oral mucosa
Non-invasive method to measure tissue blood perfusion applied for oral mucosa
wound fluid measurement
Wound fluid at the wound margin is collected using filter strip and volumetrically measured by Periotron 8010 instrument.
quantitative determination of VEGF
For the quantitative determination of VEGF in the fourth day wound fluid sample the Human VEGF Quantikine ELISA Kit will be used.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* heavy smoking
* general diseases
* taking medications or having treatments which have an effect on mucosal healing in general (e.g. steroids, anti-inflammatory drugs)
* taking any other medications in the last three months (except contraceptives)
18 Years
45 Years
ALL
Yes
Sponsors
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Hungarian Scientific Research Fund
UNKNOWN
Semmelweis University
OTHER
Responsible Party
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Dr. Vag Janos
associate professor
Principal Investigators
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Janos Vag
Role: PRINCIPAL_INVESTIGATOR
Semmelweis University, Dept. of Conservative Dentistry
Locations
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Janos Vag
Budapest, , Hungary
Countries
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Other Identifiers
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3/2013
Identifier Type: -
Identifier Source: org_study_id
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