Piezoelectric Vibrations and Tissue, Cellular and Molecular Mechanisms of Oral Wound Healing After Third Molar Surgery

NCT ID: NCT02942108

Last Updated: 2022-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-31

Study Completion Date

2020-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this clinical trial is to investigate and compare the effect of piezoelectric surgery on tissue, cellular and molecular level of oral surgical wound healing and postoperative outcomes (pain, swelling, trismus) after lower third molar surgery in healthy patients

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Tooth, Impacted

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

healthy, conventional surgery

Surgical bone removal by conventional rotary burs in healthy patients during third molar surgery

Group Type ACTIVE_COMPARATOR

conventional surgery

Intervention Type PROCEDURE

healthy, piezo surgery

Surgical bone removal by piezoelectric vibrations in healthy patients during third molar surgery

Group Type EXPERIMENTAL

piezo surgery

Intervention Type PROCEDURE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

piezo surgery

Intervention Type PROCEDURE

conventional surgery

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* bilaterally symmetrically impacted lower third molars

Exclusion Criteria

* presence of intraoral infection
* chronic orofacial pain
* pregnancy/ lactation
* heavy tobacco smokers
* alcohol/ drug abuse
* allergic reaction to medicaments used
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of Belgrade

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Bozidar Brkovic, DDS, MSc, PhD, Professor

DDS, PhD, Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Bozidar M Brkovic, DDS,PhD

Role: PRINCIPAL_INVESTIGATOR

School of Dental Medicine, University of Belgrade

Milan V Vucetic, PhD student

Role: PRINCIPAL_INVESTIGATOR

School of Dental Medicine, University of Belgrade

Marija S Milic, DDS, PhD

Role: PRINCIPAL_INVESTIGATOR

School of Dental Medicine, University of Belgrade

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

School of Dental Medicine, University of Belgrade

Belgrade, , Serbia

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Serbia

References

Explore related publications, articles, or registry entries linked to this study.

Bailey E, Kashbour W, Shah N, Worthington HV, Renton TF, Coulthard P. Surgical techniques for the removal of mandibular wisdom teeth. Cochrane Database Syst Rev. 2020 Jul 26;7(7):CD004345. doi: 10.1002/14651858.CD004345.pub3.

Reference Type DERIVED
PMID: 32712962 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

36/20

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.