Minimum Effective Volume of Lidocaine Costoclavicular Brachial Plexus Block

NCT ID: NCT02932670

Last Updated: 2017-03-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-10-31
• Study Completion Date: 2017-02-28

Brief Summary

The aim of this study is to determine the minimum effective volume of lidocaine in 90% of patients (ED90) required for single-injection US-guided costoclavicular infraclavicular.

Detailed Description

The aim of this study is to determine the minimum effective volume of lidocaine in 90% of patients (ED90) required for single-injection US-guided costoclavicular ICB. Determination of the minimum effective volume of LA is important because it prevents the administration of an unnecessarily large (and potentially toxic) dose. Furthermore, when multiple blocks need to be performed at the same time in the same patient, knowledge of the minimum effective volume allows to the operator to preserve efficacy without sacrificing safety for each block.

Conditions

Upper Extremity Surgery

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

costoclavicular inflaclavicular block

costoclavicular block with similar volume

Group Type: ACTIVE_COMPARATOR

costoclavicular nerve block

Intervention Type: OTHER

ultrasound-guided costoclavicular nerve block

costoclavicular block

costoclavicular block with decreasing volume

Group Type: EXPERIMENTAL

costoclavicular nerve block

Intervention Type: OTHER

ultrasound-guided costoclavicular nerve block

Interventions

costoclavicular nerve block

ultrasound-guided costoclavicular nerve block

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• age between 18 and 70 years
• American Society of Anesthesiologists classification 1-3
• body mass index between 20 and 30

Exclusion Criteria

• adults who are unable to give their own consent
• pre-existing neuropathy (assessed by history and physical examination)
• coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets≤ 100, International Normalized Ratio≥ 1.4 or partial prothrombin time ≥ 50)
• renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine≥ 100)
• hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases≥ 100)
• allergy to local anesthetics
• pregnancy
• prior surgery in the infraclavicular region
• chronic pain syndromes requiring opioid intake at home

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

McGill University Health Centre/Research Institute of the McGill University Health Centre

OTHER

Sponsor Role: lead

Responsible Party

De Tran

MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

De QH Tran, MD

Role: PRINCIPAL_INVESTIGATOR

McGill University Health Centre/Research Institute of the McGill University Health Centre

Locations

Montreal General Hospital

Montreal, Quebec, Canada

Countries

Canada

References

Sotthisopha T, Elgueta MF, Samerchua A, Leurcharusmee P, Tiyaprasertkul W, Gordon A, Finlayson RJ, Tran DQ. Minimum Effective Volume of Lidocaine for Ultrasound-Guided Costoclavicular Block. Reg Anesth Pain Med. 2017 Sep/Oct;42(5):571-574. doi: 10.1097/AAP.0000000000000629.

Reference Type: DERIVED

PMID: 28723837 (View on PubMed)

Other Identifiers

Montreal General Hospital

Identifier Type: -

Identifier Source: org_study_id