Ropivacaine Volume for Ultrasound-guided Retrograde Infraclavicular Brachial Plexus Block

NCT ID: NCT01334619

Last Updated: 2011-04-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-03-31
• Study Completion Date: 2010-05-31

Brief Summary

The retrograde infraclavicular brachial plexus block has been proved an effective and safe approach. Realtime ultrasound guide will facilitate a successful peripheral nerve block. The purpose of this study was to determine the medium effective volume required to produce an effective retrograde infraclavicular block using an ultrasound (US)-guided technique.

Detailed Description

Thirty adults undergoing elective upper limb surgery received an US-guided retrograde infraclavicular block. The initial concentration of 0.5% ropivacaine injected was 30 ml, which was subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient. The medium effective volume (EV50) was determined using the Dixon and Massey up-and-down method. The effective volume in 95% of patients (EV95) was calculated using probit regression.

Conditions

Upper Extremity Injury Trauma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Blinding Strategy: SINGLE

Study Groups

ropivacaine volume titration

Group Type: OTHER

appropriate volume of 0.5% ropivacaine

Intervention Type: PROCEDURE

initial concentration: 30 ml, subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient, until 5 up-and-down cycles completed.

Interventions

appropriate volume of 0.5% ropivacaine

initial concentration: 30 ml, subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient, until 5 up-and-down cycles completed.

Intervention Type: PROCEDURE

Other Intervention Names

Naropin

Eligibility Criteria

Inclusion Criteria

• Elected upper extremity operations
• BMI 17~30kg/m2
• ASA I/II

Exclusion Criteria

• Infection at injection site
• Sepsis
• Coagulation Dysfunction
• Phrenic nerve palsy
• Pneumothorax
• Recurrent laryngeal nerve palsy
• Clavicle fracture combined with nerve damage

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Beijing Jishuitan Hospital

OTHER

Sponsor Role: lead

Responsible Party

Department of Anesthesiology, Beijing Jishuitan Hosptial

Principal Investigators

Xiaoguang Zhang, MB

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing, China

Locations

Beijing jishuitan hospital

Beijing, , China

Countries

China

Other Identifiers

JSTMZ.2

Identifier Type: -

Identifier Source: org_study_id