Regional Changes in Upper Limb Perfusion Following Brachial Plexus Block: A Pilot Study

NCT ID: NCT02589054

Last Updated: 2017-03-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

18 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-11-30

Study Completion Date

2016-03-31

Brief Summary

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Ultrasound-guided regional anesthesia is increasingly being used in the modern surgical environment to provide specific intraoperative anesthesia and postoperative analgesia. Infiltration of local anesthesics around peripheral nerves firs blocks sympathetic, then sensory, then motor nerve function. Sympathectomy-induced vasodilation following brachial plexus block results in increased skin temperature and arterial flow within minutes.

Although it has not been shown to reliably increase diameter or cross-sectional area of distal arteries, brachial plexus block does change the pattern and quantity of blood flow to the hand. Given that the magnitude of change of flow cannot be attributed to vessel radius, the investigators suspect that the more laminar fluid dynamics are due to vascular tone.

The investigators study aims to quantify alterations in physiology and peripheral vasodilator response. The investigators anticipate that axially block will significantly improve regional blood flow.

Detailed Description

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Conditions

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Anesthesia, Conduction Nerve Block Sympathectomy Regional Blood Flow

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients

Monitoring

Intervention Type OTHER

Interventions

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Monitoring

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* ASA physical status I, II, III
* BMI less than or equal to 39
* Presenting for elective upper limb surgery

Exclusion Criteria

* Age over 80
* ASA physical status IV or V
* BMI greater or equal to 40
* Language barrier precluding ability to give informed consent
* History of coagulopathy
* INR \< 1.4
* Platelet count \< 100
* Allergy to local anesthetics
* Known peripheral vascular disease of the upper limbs
* Amputation of one or both upper limbs, not including digits
* Peripheral neurological disease
* Does not consent to participate in study
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Western Ontario, Canada

OTHER

Sponsor Role collaborator

London Health Sciences Centre

OTHER

Sponsor Role collaborator

St. Joseph's Health Care London

OTHER

Sponsor Role collaborator

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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106285

Identifier Type: -

Identifier Source: org_study_id

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