Study Results
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Basic Information
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COMPLETED
35 participants
OBSERVATIONAL
2016-11-30
2018-01-31
Brief Summary
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Detailed Description
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* A new polymer - nano-TiO2 composite system for dentures printing was obtained by adding 0,4-1%TiO2 nanoparticle in the commercially available E-Dent 100 (EnvisionTEC, Germany).
* The new polymer was completely characterized and biocompatibility tests were perform.
* A stereolithography technique was set-up for CAD-CAM complete dentures manufacturing.
* 3D printed dental prosthesis will be inserted to a number of 35 complete edentulous patients from a target group;
* Clinical follow-up at 6, 12 and 18 months and quality assessment of the dentures will be recorded in a specific chart.
* A statistical evaluation of data recorded during the entire follow-up period will be performed.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Persons having mental competence, decision-making capacity, legal competence.
* Patients willing to accept complete denture treatment.
* Patients with good systemic health, able to attend all the follow-up sessions.
* Patients accepting the participation in the study, including the 18 months follow-up and signing the consent form.
Exclusion Criteria
* Patients refusing participation in the study and signing consent form.
* Patients not willing removable dental restorations.
* Patients not willing to participate at 18 months follow-up evaluation.
18 Years
99 Years
ALL
Yes
Sponsors
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Carol Davila University of Medicine and Pharmacy
OTHER
Romanian National Authority for Scientific Research and Innovation (UEFISCIDI)
UNKNOWN
University Politechnica of Bucharest
UNKNOWN
TURKEY MEDISEN Ltd
UNKNOWN
DDX Europa SRL, Bucharest, Romania
UNKNOWN
Corina Marilena Cristache
OTHER
Responsible Party
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Corina Marilena Cristache
Senior Lecturer, PhD, Dr
Principal Investigators
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Eugenia Eftimie Totu, Prof.
Role: STUDY_DIRECTOR
UNIV. POLITEHNICA OF BUCHAREST
Locations
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"Carol Davila"University of Medicine and Pharmacy
Bucharest, , Romania
Countries
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References
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Wang Y, Wen C, Hodgson P, Li Y. Biocompatibility of TiO2 nanotubes with different topographies. J Biomed Mater Res A. 2014 Mar;102(3):743-51. doi: 10.1002/jbm.a.34738. Epub 2013 Jun 1.
Mallineni SK, Nuvvula S, Matinlinna JP, Yiu CK, King NM. Biocompatibility of various dental materials in contemporary dentistry: a narrative insight. J Investig Clin Dent. 2013 Feb;4(1):9-19. doi: 10.1111/j.2041-1626.2012.00140.x. Epub 2012 Dec 17.
Kummer KM, Taylor EN, Durmas NG, Tarquinio KM, Ercan B, Webster TJ. Effects of different sterilization techniques and varying anodized TiO(2) nanotube dimensions on bacteria growth. J Biomed Mater Res B Appl Biomater. 2013 Jul;101(5):677-88. doi: 10.1002/jbm.b.32870. Epub 2013 Jan 29.
Kane RJ, Yue W, Mason JJ, Roeder RK. Improved fatigue life of acrylic bone cements reinforced with zirconia fibers. J Mech Behav Biomed Mater. 2010 Oct;3(7):504-11. doi: 10.1016/j.jmbbm.2010.05.007. Epub 2010 Jun 8.
Gautam R, Singh RD, Sharma VP, Siddhartha R, Chand P, Kumar R. Biocompatibility of polymethylmethacrylate resins used in dentistry. J Biomed Mater Res B Appl Biomater. 2012 Jul;100(5):1444-50. doi: 10.1002/jbm.b.32673. Epub 2012 Mar 27.
Tsuji M, Ueda T, Sawaki K, Kawaguchi M, Sakurai K. Biocompatibility of a titanium dioxide-coating method for denture base acrylic resin. Gerodontology. 2016 Dec;33(4):539-544. doi: 10.1111/ger.12204. Epub 2015 Jul 30.
Totu EE, Nechifor AC, Nechifor G, Aboul-Enein HY, Cristache CM. Poly(methyl methacrylate) with TiO2 nanoparticles inclusion for stereolitographic complete denture manufacturing - the fututre in dental care for elderly edentulous patients? J Dent. 2017 Apr;59:68-77. doi: 10.1016/j.jdent.2017.02.012. Epub 2017 Feb 20.
Related Links
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Link to the PRIDENTPRO project.
Other Identifiers
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CCDI-UEFISCDI 30/2016
Identifier Type: -
Identifier Source: org_study_id
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