Does Abatacept Induce Regulatory B Cells in Patients With Rheumatoid Arthritis

NCT ID: NCT02885818

Last Updated: 2019-04-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-10-01

Study Completion Date

2018-01-11

Brief Summary

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Abatacept disrupts T-cell coactivation signals in rheumatoid arthritis (RA). Its potential effects on B cells are not well described. This study will assess the effects of abatacept therapy on the phenotype and function of peripheral blood B cells in patients with RA.

Detailed Description

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Conditions

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Rheumatoid Arthritis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* RA as defined by ACR/EULAR criteria
* Clinical indication to start abatacept therapy

Exclusion Criteria

* Treatment by rituximab in the previous year
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Brest

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jacques-Olivier Pers

Role: STUDY_DIRECTOR

CHRU de Brest

Locations

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CHRU de Brest

Brest, , France

Site Status

Countries

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France

Other Identifiers

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ABATACEPT AND B CELL

Identifier Type: -

Identifier Source: org_study_id

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