Long-Term Outcomes With Abatacept In Biologic Treatment-Naive Rheumatoid Arthritis Patients In Japanese Clinical Practice Settings

NCT ID: NCT02758769

Last Updated: 2025-06-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

303 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-06-07

Study Completion Date

2023-11-15

Brief Summary

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The purpose of this study is to examine the effectiveness and safety of the abatacept administration in biologic-naïve rheumatoid arthritis patients who have moderate disease activity despite treatments with conventional synthetic disease modified anti-rheumatic drugs.

Detailed Description

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Conditions

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Rheumatoid Arthritis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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ORENCIA with Exposure

ORENCIA with Exposure

ORENCIA Subcutaneous Injection

Intervention Type BIOLOGICAL

Interventions

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ORENCIA Subcutaneous Injection

Intervention Type BIOLOGICAL

Other Intervention Names

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Abatacept

Eligibility Criteria

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Inclusion Criteria

* Patients with RA who meet the 2010 American College of Rheumatology / European League against Rheumatisms (ACR/EULAR) RA Classification Criteria
* Patients with RA with a moderate disease activity (SDAI: \> 11 and 26)
* Biologic-naive patients with treatment history csDMARDs
* Patients who meet the following criteria by hematological examination:

* Peripheral white blood cell count: 4,000/mm3
* Peripheral lymphocyte count: 1,000/mm3
* Blood β-D-glucan negative
* Patients who understand the investigator's explanation of study procedures and have given voluntary written consent to participate in this study
* Patients initiated with abatacept at per their physician's therapeutic decision

Exclusion Criteria

* Past history of hypersensitivity to the components of the abatacept preparation
* Disease complications from a comorbidity
* Active infectious disease
* Been judged by the investigator or the co-investigator as being inappropriate
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ono Pharmaceutical Co. Ltd

INDUSTRY

Sponsor Role collaborator

Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Local Institution - 0001

Minato-ku, Tokyo, Japan

Site Status

Local Institution

Minato-ku, Tokyo, Japan

Site Status

Countries

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Japan

Related Links

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Other Identifiers

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IM101-574

Identifier Type: -

Identifier Source: org_study_id

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