Structural and Functional Brain Reorganization in Neuropathic Pain. Influences of the Loss of Sensitivity and the Atrophy Cortical on Activations Due to Stimulation Allodynic
NCT ID: NCT02858479
Last Updated: 2020-09-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
41 participants
INTERVENTIONAL
2016-03-25
2019-02-11
Brief Summary
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This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain. It induces a loss of sensitivity and reorganization of brain activity.
Previous studies in functional neuroimaging have focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally.
The objective of this study is to understand the brain dysfunction that induces allodynic pain considering the deafferentation of each patient and possible cortical losses.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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patients with pain allodynic peripheral
stimulation on painful area (area allodynic)
these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable.
stimulations for 6 seconds
same stimulation on non-painful area
these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable.
stimulations for 6 seconds
MRI scan
2 sessions for 10 minutes :
* 11 controls stimulations for 6 s each spaced 20 s without stimulation.
* 11 allodynic stimulations for 6 s each spaced 20 s without stimulation.
patients with pain allodynic central
stimulation on painful area (area allodynic)
these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable.
stimulations for 6 seconds
same stimulation on non-painful area
these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable.
stimulations for 6 seconds
MRI scan
2 sessions for 10 minutes :
* 11 controls stimulations for 6 s each spaced 20 s without stimulation.
* 11 allodynic stimulations for 6 s each spaced 20 s without stimulation.
Interventions
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stimulation on painful area (area allodynic)
these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable.
stimulations for 6 seconds
same stimulation on non-painful area
these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable.
stimulations for 6 seconds
MRI scan
2 sessions for 10 minutes :
* 11 controls stimulations for 6 s each spaced 20 s without stimulation.
* 11 allodynic stimulations for 6 s each spaced 20 s without stimulation.
Eligibility Criteria
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Inclusion Criteria
* in the case of central lesions, the lesion must be unique and small
* treatment not stable opioid for one week
* consent signed
Exclusion Criteria
* presence of an evolutive lesion, expansive, cancerous or tumorous underlying
* patient needing of opioid therapy
* contraindication at MRI scan
18 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de Saint Etienne
OTHER
Responsible Party
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Principal Investigators
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Roland PEYRON, MD
Role: PRINCIPAL_INVESTIGATOR
CHU de SAINT-ETIENNE
Locations
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CHU de SAINT-ETIENNE
Saint-Etienne, , France
Countries
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Other Identifiers
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2013-A01791-44
Identifier Type: OTHER
Identifier Source: secondary_id
1308174
Identifier Type: -
Identifier Source: org_study_id
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