Structural and Functional Brain Reorganization in Neuropathic Pain: Basal State of Local Cerebral Blood Flow and Functional Connectivity
NCT ID: NCT02858466
Last Updated: 2020-09-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
68 participants
INTERVENTIONAL
2016-03-25
2019-03-22
Brief Summary
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This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain.
It induces a loss of sensitivity and likely reorganization of brain activity that are causing pain and which are the subject of this study.
Previous studies in functional neuroimaging has focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally. The authors failed to assess the part of the effect of the loss of sensory afferents (deafferentation) and the basal brain function.
Indeed, the operation without any sensory stimulation is not known yet is the initial level of activity which is the benchmark for studying brain function during stimulation. The objective of this study is to understand what are the cortical systems of allodynic dysfunctional in patients compared with controls at baseline.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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peripheric nervous lesion
MRI scan
MRI scan
medullar or encephalic lesion
MRI scan
MRI scan
control group
MRI scan
MRI scan
Interventions
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MRI scan
Eligibility Criteria
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Inclusion Criteria
* with nervous pain : chronic or peripheric
* treatment not stable opioid since one week
* signed consent
* major
* without chronic pain
* signed consent
Exclusion Criteria
* presence of an active nervous lesion
* subject with morphine treatment
* contraindication to MRI scan
18 Years
ALL
Yes
Sponsors
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Centre Hospitalier Universitaire de Saint Etienne
OTHER
Responsible Party
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Principal Investigators
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Roland PEYRON, MD
Role: PRINCIPAL_INVESTIGATOR
CHU de SAINT-ETIENNE
Locations
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CHU de SAINT-ETIENNE
Saint-Etienne, , France
Countries
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Other Identifiers
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2013-A01440-45
Identifier Type: OTHER
Identifier Source: secondary_id
1308144
Identifier Type: -
Identifier Source: org_study_id
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