Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
47 participants
INTERVENTIONAL
2010-04-30
2017-12-31
Brief Summary
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The pathophysiology of sleepwalking remains poorly understood. Sleepwalkers had difficulty maintaining stable, consolidated sleep and experienced more arousals and microarousals, specifically from SWS, leading to increased NREM instability, especially during the first sleep cycles. The brain is partially awake, resulting in behavioral manifestations, and partially in NREM sleep, resulting in no conscious awareness of actions.
A Single Photonic Emission Computed Tomography (SPECT) study of one sleepwalking episode found increased activation in the posterior cingulate cortex and cerebellum, with deactivation in the frontoparietal associative cortices. Data from intracerebral EEGs during confusional arousals confirmed both local arousal of the motor and cingulate cortices and increased delta activity in the frontoparietal associative cortices.
The investigators thus proposed a controlled study of SPECT imagery in 24 sleepwalkers (12 SPECT during a SW episode and 12 SPECT during slow wave sleep and 24 during wakefulness) and 12 controls (during slow wave sleep and wakefulness). SW episodes will be elicited by sleep deprivation condition associated with forced arousal (auditory stimulus).
The comparative analyses of SPECT acquisitions between different states (wakefulness, slow wave sleep and SW) and populations (sleepwalkers versus controls) will provide new insights about the complex pathophysiology of SW episodes.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Sleepwalker, SW episode
Sleepwalker patients undergo single-photon emission computed tomography during a sleepwalking episode.
Single-photon emission computed tomography
Sleepwalkers, slow wave sleep
Sleepwalker patients undergo single-photon emission computed tomography during slow-wave sleep.
Single-photon emission computed tomography
Control group
Control subjects undergo single-photon emission computed tomography during slow-wave sleep.
Single-photon emission computed tomography
Interventions
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Single-photon emission computed tomography
Eligibility Criteria
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Inclusion Criteria
* More than one episode per week
* More than one hypersynchronous delta wave arousal recorded on polysomnographic assessment
* Affiliated to social security
* Age between 18 years-old and 39 years-old
* Affiliated to social security
* Age between 18 years-old and 39 years-old
Exclusion Criteria
* Patient with obstructive sleep apnea Syndrome, restless legs syndrome, nocturnal epilepsy and unstable psychiatric disease.
CONTROL GROUP
* Subject taking psychotropic drug during the two weeks before the inclusion
* Subject with following medical history : NREM parasomnia, neurologic or psychiatric disorder, obstructive sleep apnea syndrome, restless legs syndrome, nocturnal epilepsy.
18 Years
39 Years
ALL
Yes
Sponsors
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University Hospital, Montpellier
OTHER
Responsible Party
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Locations
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University Hospital of Montpellier
Montpellier, , France
Countries
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Other Identifiers
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UF 8585
Identifier Type: -
Identifier Source: org_study_id
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