High-intensity Interval Training Enhances Mobilization/Functionality of Endothelial Progenitor Cells and Depressed Shedding of Vascular Endothelial Cells Undergoing Hypoxia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-12-31

Study Completion Date

2013-12-31

Brief Summary

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Exercise training improves endothelium-dependent vasodilation, whereas hypoxic stress causes vascular endothelial dysfunction. Monocyte- derived endothelial progenitor cells (Mon-EPCs) contribute to vascular repair process by differentiating into endothelial cells. This study investigates how high-intensity interval (HIT) and moderate intensity-continuous (MCT) exercise training affect circulating Mon-EPC levels and EPC functionality under hypoxic condition. Sixty healthy sedentary males were randomized to engage either HIT (3-minute intervals at 40% and 80%VO2max , n=20) or MCT (sustained 60%VO2max , n=20) for 30 minutes/day, 5 days/week for 6 weeks, or to a control group that did not received exercise intervention (n=20). Mon-EPC characteristics and EPC functionality under hypoxic exercise (HE, 100W under 12%O 2 ) were determined before and after various interventions.

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Detailed Description

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Conditions

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Hypoxia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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High intensity-interval (HIT)

Group Type EXPERIMENTAL

HIT

Intervention Type BEHAVIORAL

3-minute intervals at 40% and 80%VO 2max

moderate intensity-continuous (MCT)

Group Type EXPERIMENTAL

MCT

Intervention Type BEHAVIORAL

sustained 60%VO 2max

control (CTL)

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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HIT

3-minute intervals at 40% and 80%VO 2max

Intervention Type BEHAVIORAL

MCT

sustained 60%VO 2max

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Sedentary life
* Age 20\~28

Exclusion Criteria

* Smokers
* Users of medication/vitamins
* Any cardiopulmonary/hematological risk
* Regular exercise habits at least 1 year
* Exposed to high altitudes (\>3000 m) for at least 1 year

Minimum Eligible Age

20 Years

Maximum Eligible Age

28 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes