Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes

NCT ID: NCT01176578

Last Updated: 2025-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2026-12-31

Brief Summary

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The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.

Detailed Description

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Conditions

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Type 2 Diabetes Mellitus

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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T2DM

Type 2 Diabetes Mellitus

Group Type EXPERIMENTAL

Aerobic Exercise Training

Intervention Type OTHER

6 months of aerobic exercise training, 3 days per week

IGT

Impaired Glucose Tolerance

Group Type EXPERIMENTAL

Aerobic Exercise Training

Intervention Type OTHER

6 months of aerobic exercise training, 3 days per week

NGT

Normal Glucose Tolerance

Group Type ACTIVE_COMPARATOR

Aerobic Exercise Training

Intervention Type OTHER

6 months of aerobic exercise training, 3 days per week

Interventions

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Aerobic Exercise Training

6 months of aerobic exercise training, 3 days per week

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age 50-80
* Non-smoker
* If woman, postmenopausal \>1 year

Exclusion Criteria

* History of heart disease or stroke
* Cancer
* Poorly controlled hypertension or dyslipidemia
* Kidney or Liver diseases
Minimum Eligible Age

50 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Maryland, Baltimore

OTHER

Sponsor Role collaborator

Baltimore VA Medical Center

FED

Sponsor Role lead

Responsible Party

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Steven J. Prior, Ph.D.

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Baltimore VA Medical Center

Baltimore, Maryland, United States

Site Status

Countries

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United States

Other Identifiers

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HP-00047188

Identifier Type: -

Identifier Source: org_study_id

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