Assessment of Postoperative Lymphopenia as Risk Factor for Postoperative Infections
NCT ID: NCT02799251
Last Updated: 2021-01-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
1125 participants
OBSERVATIONAL
2016-06-30
2017-07-31
Brief Summary
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Detailed Description
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The aim of this study is to determine if lymphopenia is associated with postoperative infections in thoracic and digestive cancer surgery. It is a multicenter French cohort study. Lymphocytes counts are obtained from patients undergoing pulmonary or digestive cancer surgery before surgery (day-0) as well 1, 3, 5 and 8 days after surgery. Anesthetic and surgical procedures are collected as well as risk factors for postoperative infections recognized in the literature. Clinical and biological signs of infection are collected.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Collection of plasma cell rate
Post operative infections and their association with lymphopenia are assessed in this study for patients over 18 years of age undergoing digestive or thoracic cancer surgery under general anesthesia.
Collection of plasma cell rate
Lymphocytes counts are obtained from patients undergoing pulmonary or digestive cancer surgery. The rates are assessed before surgery (day 0) and at days 1, 3, 5 and 8 after surgery. Anesthetic and surgical procedures are collected as well as risk factors for postoperative infections recognized in the literature. Clinical and biological signs of infection are collected.
Interventions
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Collection of plasma cell rate
Lymphocytes counts are obtained from patients undergoing pulmonary or digestive cancer surgery. The rates are assessed before surgery (day 0) and at days 1, 3, 5 and 8 after surgery. Anesthetic and surgical procedures are collected as well as risk factors for postoperative infections recognized in the literature. Clinical and biological signs of infection are collected.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* malignant blood disease,
* allograft patient,
* preoperative sepsis or preoperative systemic inflammatory response syndrome.
18 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de Saint Etienne
OTHER
Responsible Party
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Principal Investigators
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Serge Molliex, PhD
Role: PRINCIPAL_INVESTIGATOR
CHU de Saint-Etienne
Locations
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Chu Angers
Angers, , France
Hôpital Côtes de Nacre CHU CAEN
Caen, , France
Hôpital Estaing CHU CLERMONT-FERRAND
Clermont-Ferrand, , France
Hôpital Beaujon CHU PARIS 1
Clichy, , France
Hôpital Michallon CHU GRENOBLE
La Tronche, , France
Hôpital Huriez CHRU LILLE
Lille, , France
Hôpital Edouard Herriot CHU LYON
Lyon, , France
Hôpital La croix Rousse CHU LYON
Lyon, , France
Hôpital Lyon Sud CHU LYON
Lyon, , France
Hôpital Nord CHU MARSEILLE
Marseille, , France
Hôpital La Timone CHU MARSEILLE
Marseille, , France
Hôpital Hôtel-Dieu CHU NANTES
Nantes, , France
Hôpital Carémeau CHU NIMES
Nîmes, , France
Hôpital Saint Louis-Lariboisière CHU PARIS 5
Paris, , France
Hôpital Saint-Antoine CHU PARIS 4
Paris, , France
Hôpital La pitié-Salpetrière CHU PARIS 3
Paris, , France
Hôpital Bichat CHU PARIS 2
Paris, , France
Hôpital Pontchaillou CHU RENNES
Rennes, , France
Hôpital Central CHRU STRASBOURG
Strasbourg, , France
Centre de Lutte contre le Cancer, TOULOUSE
Toulouse, , France
Countries
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References
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Petit L, Pastene B, Dupont G, Baffeleuf B, Goulevant PA, Fellahi JL, Gricourt Y, Lebuffe G, Ouattara A, Fischer MO, Mertes PM, Eyraud D, Bouhemad B, Gomola A, Montravers P, Alingrin J, Flory L, Incagnoli P, Boisson M, Leone M, Monneret G, Lukaszewicz AC, Pereira B, Molliex S; for the EVALYMPH study group. Postoperative lymphopaenia as a risk factor for postoperative infections in cancer surgery: A prospective multicentre cohort study (the EVALYMPH study). Eur J Anaesthesiol. 2025 Mar 1;42(3):244-254. doi: 10.1097/EJA.0000000000002089. Epub 2024 Oct 29.
Other Identifiers
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1600010
Identifier Type: -
Identifier Source: org_study_id
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