Evaluation of the Impact of Pancreatectomy on Systemic Immunity

NCT ID: NCT03978702

Last Updated: 2022-01-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-24

Study Completion Date

2022-07-27

Brief Summary

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The study aims at establishing the profile of the immune reaction that occurs in the early surgical suites after pancreatectomy. Blood samples will be collected before surgery, (Day-1), at day0, and after surgery at Day 1, Day 3, Day 7 at 1 year after pancreatectomy. Mass cytometry, genomic and transcriptomic approaches will be used to evaluate the immune systemic modulation after surgery.

Detailed Description

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Conditions

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Pancreas Cancer Pancreatectomy; Hyperglycemia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Indication for pancreatectomy

Blood sampling at different time points before and after pancreatectomy

Group Type EXPERIMENTAL

Blood sampling

Intervention Type OTHER

20 mL will be collected at each time point (day-1,day 0, day 1, day 3, day 7, 1 year after pancreatectomy)

Interventions

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Blood sampling

20 mL will be collected at each time point (day-1,day 0, day 1, day 3, day 7, 1 year after pancreatectomy)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patient with an indication of pancreatectomy
* Signed consent form

Exclusion Criteria

* Neoadjuvant treatment
* Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut Paoli-Calmettes

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Olivier Turrini, MD ¨PhD

Role: PRINCIPAL_INVESTIGATOR

Institut Paoli-Calmettes

Locations

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Institut Paoli Calmettes

Marseille, , France

Site Status

Countries

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France

Other Identifiers

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IMMUNOPANC-IPC 2018-051

Identifier Type: -

Identifier Source: org_study_id

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